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02:26
Intracranial Pharmacotherapy and Pain Assays in Rodents
Published on: April 9, 2019
The Brain in Pain: Exploring Central Pain Disorders.
Keith Polston1, Francesco Maoli2, Meron Selassie3
1Department of Orthopaedics and Physical Medicine & Rehabilitation, Medical University of South Carolina.
Summary
Central pain syndromes result from central nervous system damage or dysfunction. This review covers pain theory evolution, central pain, centralization, nociplastic pain, and related neurobiology, diagnostics, and therapies.
Area of Science:
- Neurology
- Pain Medicine
- Neuroscience
Background:
- Central pain syndromes (CPS) stem from damage or dysfunction within the central nervous system (CNS).
- Understanding CPS has evolved through historical and modern medical models.
- Distinguishing CPS from centralization and nociplastic pain is crucial for accurate diagnosis and treatment.
Purpose of the Study:
- To provide a comprehensive overview of central pain syndromes.
- To trace the historical development of pain theory.
- To discuss current understanding, diagnosis, and management of CPS.
Main Methods:
- Literature review of pain theory evolution.
- Exploration of neuroanatomy and physiology related to pain pathways.
- Discussion of key pathologies causing central pain.
- Overview of diagnostic approaches and clinical therapies.
Main Results:
- Central pain syndromes are distinct from centralization and nociplastic pain.
- Stroke, traumatic brain injury, and spinal cord injury are significant causes of central pain.
- A range of diagnostic tools and therapeutic interventions are available for managing CPS.
Conclusions:
- Central pain syndromes represent a complex neurological challenge requiring a thorough understanding of pain mechanisms.
- Advances in neuroanatomy, physiology, and pathology inform current diagnostic and therapeutic strategies.
- Future research holds promise for novel treatments and improved management of central pain.
![Autoradiographic Measurements of [14C]-Iodoantipyrine in Rat Brain Following Central Post-Stroke Pain](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F53947.jpg&w=3840&q=50)
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