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Cardiopulmonary interactions during paediatric mechanical ventilation: protocol for a scoping review.
Richard A Hollander1,2, Jeroen Ter Horst3, Sjoukje van der Werf4
1Department of Paediatrics, Division of Paediatric Critical Care Medicine, University Medical Centre Groningen Beatrix Children's Hospital, Groningen, GR, Netherlands r.a.hollander@umcg.nl.
BMJ Open
|June 30, 2026
Summary
This scoping review examines mechanical ventilation
Area of Science:
- Pediatric Critical Care
- Cardiopulmonary Physiology
- Mechanical Ventilation
Background:
- The heart and lungs share thoracic space, impacting cardiopulmonary dynamics.
- Positive pressure ventilation significantly alters circulation, with limited pediatric data.
- Current pediatric mechanical ventilation principles often extrapolate from adult/animal studies.
Purpose of the Study:
- To summarize evidence on mechanical ventilation's circulatory effects in critically ill children.
- To identify knowledge gaps in pediatric mechanical ventilation research.
Main Methods:
- Scoping review following Joanna Briggs Institute (JBI) protocol.
- Comprehensive search of major databases (PubMed, Embase, CENTRAL, Web of Science) and clinical trial registries.
- Systematic screening and data extraction by independent reviewers, adhering to PRISMA Extension for Scoping Reviews.
Main Results:
- Data on cardiovascular outcomes related to ventilatory changes in children are limited.
- Evidence synthesis will highlight specific impacts of ventilation parameters on pediatric circulation.
- Knowledge gaps concerning the precise effects of mechanical ventilation on pediatric hemodynamics will be identified.
Conclusions:
- Further research is needed to clarify mechanical ventilation's impact on pediatric circulation.
- Evidence-based guidelines for mechanical ventilation in pediatric critical care require strengthening.
- This review will inform future studies and clinical practice for improved pediatric patient outcomes.
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