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Related Experiment Video

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A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors
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Exploratory Analysis of VEGF Polymorphisms and Colorectal Cancer Risk in a Hungarian Population: A Case-Control

Krisztina Varajti1, Andrea Vereczkei2, Márk Kovács-Valasek3

  • 1Department of Public Health Medicine, Medical School, University of Pécs, Pécs, Hungary; varajti.krisztina@edu.pte.hu.

In Vivo (Athens, Greece)
|June 30, 2026
PubMed
Summary

This pilot study investigated genetic variants in Hungarian colorectal cancer (CRC) patients. Two vascular endothelial growth factor (VEGF) gene variants showed potential associations with CRC risk, warranting further research.

Keywords:
ALDH2Colorectal cancerHungarian populationTNF-αVEGFcase-control studysingle nucleotide polymorphism

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Published on: September 3, 2021

Area of Science:

  • Genetics and Genomics
  • Oncology
  • Molecular Biology

Background:

  • Colorectal cancer (CRC) has high incidence and mortality rates in Hungary.
  • Genetic factors influencing inflammation, vascular development, and alcohol metabolism may impact CRC susceptibility.
  • Investigating specific gene polymorphisms is crucial for understanding CRC risk.

Purpose of the Study:

  • To examine the association between specific polymorphisms in ALDH2, TNF-α, and VEGF genes and colorectal cancer risk in a Hungarian population.
  • To utilize a candidate gene approach for identifying potential genetic modulators of CRC.
  • To provide preliminary data for larger-scale genetic association studies.

Main Methods:

  • A case-control study design was employed with 89 Hungarian participants (36 CRC patients, 53 controls).
  • Genotyping of four single nucleotide polymorphisms (SNPs) (rs886205, rs1800629, rs2010963, rs699947) was performed using TaqMan-based qPCR.
  • Statistical analyses included logistic regression with various genetic models, adjusted for sex, and sex-stratification.

Main Results:

  • Two VEGF gene variants, rs699947 (AA genotype, recessive model) and rs2010963 (C allele, dominant model), showed nominal associations with CRC risk.
  • The rs699947 AA genotype was linked to increased CRC risk (OR=2.97), while rs2010963 C allele suggested a protective effect, especially in males (OR=0.23).
  • No significant associations were found for ALDH2 or TNF-α polymorphisms, potentially due to small sample size and genotype distribution.

Conclusions:

  • Despite the small sample size, findings suggest that two VEGF polymorphisms may influence CRC risk in the Hungarian population.
  • These results highlight the potential role of VEGF in CRC pathogenesis.
  • Larger, independent cohort studies are recommended to validate these preliminary findings and confirm the role of these genetic variants.