Related Experiment Video

Updated: Jul 2, 2026

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
08:10

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation

Published on: July 20, 2022

Atrial Fibrillation and Lipid-related Indices in Japanese Men: An Age-matched Case-control Study

Ichiro Wakabayashi1

  • 1Department of Preventive Medicine, School of Medicine, Hyogo Medical University, Nishinomiya, Japan wakabaya@hyo-med.ac.jp.

In Vivo (Athens, Greece)
|June 30, 2026
PubMed

Insights

Certain lipid indices like LAP and GGT/HDL-C are linked to atrial fibrillation (AF), while LDL-C/HDL-C is inversely associated. A new AF risk index (AFRI) shows promise for predicting AF risk.

Area of Science:

  • Cardiology
  • Metabolic Syndrome
  • Lipidology

Background:

  • Atrial fibrillation (AF) is linked to cardiovascular risk factors.
  • The predictive value of lipid-related indices for AF remains unclear.
  • Existing indices like LDL-C/HDL-C, TG/HDL-C, LAP, CMI, and GGT/HDL-C are established cardiovascular disease predictors.

Purpose of the Study:

  • To investigate the association between various lipid-related indices and atrial fibrillation (AF).
  • To evaluate the potential of these indices, including novel ones, in predicting AF risk.

Main Methods:

  • A case-control study involving 154 men with AF and 308 age-matched controls.
  • Comparison of cardiovascular risk factors and lipid indices between AF and control groups.
  • Development and evaluation of a novel AF risk index (AFRI).

Main Results:

  • Lipid Accumulation Product (LAP) and Gamma-Glutamyltransferase/High-Density Lipoprotein Cholesterol (GGT/HDL-C) were significantly higher in the AF group.
  • Low-Density Lipoprotein Cholesterol/High-Density Lipoprotein Cholesterol (LDL-C/HDL-C) was significantly lower in the AF group.
  • The novel AF Risk Index (AFRI) demonstrated a stronger association with AF than individual risk factors.

Conclusions:

  • LAP and GGT/HDL-C show a positive association with AF.
  • LDL-C/HDL-C exhibits an inverse association with AF.
  • AFRI may serve as a valuable biomarker for AF risk stratification.
Abstract

Keywords:
Atrial fibrillationLDL cholesterolcardiovascular risk factorgamma-glutamyltransferaselipid-related indexobesity

More Related Videos

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation28:13

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Published on: February 26, 2013

Related Concept Videos

Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...