Course of Step Counts During Systemic Treatment for Non-small Cell Lung Cancer-Observational Data from a Prematurely...

Area of Science:

• Oncology
• Digital Health
• Patient Monitoring

Background:

• Systemic treatment for non-small cell lung cancer (NSCLC) can lead to fatigue and reduced physical activity.
• Assessing physical activity levels, such as daily step counts, is crucial for managing NSCLC patients.
• The APACHIE-01 trial was designed to explore step counts during treatment.

Purpose of the Study:

• To investigate the step counts of patients undergoing systemic treatment for NSCLC.
• To gather data to support a future trial of a reminder app for physical activity.

Main Methods:

• The APACHIE-01 trial aimed to recruit 38 advanced NSCLC patients.
• The primary endpoint was mean weekly step count during the first three cycles of treatment.
• The trial was stopped prematurely due to very low patient recruitment (3 patients).

Main Results:

• Mean weekly step counts at baseline were approximately 4,859 steps.
• Mean weekly step counts decreased during treatment, particularly by week nine (1,224 steps).
• Analyses were descriptive and exploratory due to the small sample size.

Conclusions:

• Patient recruitment for the APACHIE-01 trial was unexpectedly difficult.
• The observed decrease in step counts suggests potential benefits of further investigation.
• The findings support the concept of a reminder app to encourage daily walking for NSCLC patients.