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Updated: Jul 2, 2026
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Published on: October 31, 2025
Nutritional Support for Treatment Continuity and Survival in Advanced Gastric Cancer: A Propensity Score-matched
Keiji Sugiyama1,2, Takumi Ito3, Masahiro Yaguchi3
1Department of Medical Oncology, NHO Nagoya Medical Center, Aichi, Japan; keiji.sugi@gmail.com.
In Vivo (Athens, Greece)
|June 30, 2026
Summary
Nutritional support did not significantly improve time to treatment failure in advanced gastric cancer (AGC) patients overall. However, it benefited patients with low albumin levels and predicted treatment continuity in multivariate analysis.
Area of Science:
- Oncology
- Clinical Nutrition
- Gastroenterology
Background:
- Advanced gastric cancer (AGC) patients undergoing chemotherapy often face nutritional challenges.
- Optimizing nutritional status is crucial for treatment adherence and outcomes.
Purpose of the Study:
- To evaluate the impact of nutritional support on treatment outcomes in patients with advanced gastric cancer receiving first-line chemotherapy.
- To identify subgroups that may benefit most from nutritional interventions.
Main Methods:
- Retrospective review of 324 advanced gastric cancer patients receiving first-line chemotherapy.
- Comparison between patients with and without nutritional support, utilizing propensity score matching (PSM).
- Primary endpoint: time to treatment failure (TTF); subgroup analysis by baseline albumin levels.
Main Results:
- Nutritional support did not significantly alter median TTF in the overall cohort after PSM (4.6 vs. 5.0 months).
- Patients with hypoalbuminemia (albumin <3.5 g/dL) showed a significant prolongation of TTF with nutritional support.
- Multivariate analysis identified nutritional support as an independent predictor of TTF in the pre-PSM cohort.
Conclusions:
- Nutritional support may not improve TTF in all advanced gastric cancer patients but is vital for those with hypoalbuminemia.
- Targeted nutritional interventions are essential for this vulnerable subgroup to ensure treatment continuity.
- Nutritional support acts as an independent predictor of treatment continuity.
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