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Updated: Jul 2, 2026

A Modeling and Simulation Method for Preliminary Design of an Electro-Variable Displacement Pump
Published on: June 1, 2022
Make uphill thermodynamics downhill in pathway design
Junhua Guo1, Jinpeng Wang2, Yuxiang Hong2
1Department of Mechanical Engineering, Guangdong Technion - Israel Institute of Technology (GTIIT), Shantou 515063, China; Department of Chemical Engineering and Guangdong Provincial Key Laboratory of Materials and Technologies for Energy Conversion, Guangdong Technion - Israel Institute of Technology (GTIIT), Shantou, Guangdong 515063, China.
Abstract:
Metabolic engineering efforts are determined not only by enzyme activity but also by the thermodynamic driving force. This forum argues that many 'novel' synthetic routes merely relocate energetic penalties rather than eliminate them and demonstrates why evaluating Gibbs free energy change under physiological conditions is essential for robust, optimal pathway design.
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