Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
Neural Regulation01:37

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparative analysis of procedural variations in the social defeat stress paradigm in mice: effects of post-defeat housing conditions and aggressor exposure duration.

Molecular brain·2026
Same author

Increased Cerebrospinal Fluid Lactate Levels in Schizophrenia and Major Depressive Disorder: NCNP Biobank Study in Japan.

Neuropsychopharmacology reports·2026
Same author

Dendritic compartment-specific spine formation in layer 5 neurons underlies cortical circuit maturation during adolescence.

Science advances·2026
Same author

Hyper-maturity and accelerated aging in the hippocampus of mouse models of neuropsychiatric disorders with anxiety-like behavior.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2025
Same author

Remote spatial memory deficits in mouse models of neuropsychiatric disorders with immature dentate gyrus phenotype.

The international journal of neuropsychopharmacology·2025
Same author

Gene Expression Signatures of Immaturity, Decreased pH, and Neural Hyperexcitation in the Hippocampus of Alzheimer's Disease Model Mice.

Neuropsychopharmacology reports·2025

Related Experiment Video

Updated: Jul 2, 2026

Establishing a Device for Sleep Deprivation in Mice
05:05

Establishing a Device for Sleep Deprivation in Mice

Published on: September 22, 2023

Sleep Deprivation and Neuronal Hyperexcitation Share Transcriptomic Signatures.

Markos Michail Chatzigiannis1,2, Hideo Hagihara2, Tsuyoshi Miyakawa2

  • 1Department of Systems Medical Science, Fujita Health University Graduate School of Medicine, Toyoake, Aichi, Japan.

Neuropsychopharmacology Reports
|June 30, 2026
PubMed
Summary
This summary is machine-generated.

Sleep deprivation (SD) shares molecular signatures with neuronal hyperexcitation, revealing shared pathways in brain cells. This finding links sleep loss to neuropsychiatric disorders through common gene expression patterns.

Keywords:
hyperexcitationimmediate‐early genesinflammationsleep deprivationtranscriptome

More Related Videos

Chronic Sleep Deprivation in Mouse Pups by Means of Gentle Handling
03:46

Chronic Sleep Deprivation in Mouse Pups by Means of Gentle Handling

Published on: October 11, 2018

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
06:23

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

Published on: September 22, 2020

Related Experiment Videos

Last Updated: Jul 2, 2026

Establishing a Device for Sleep Deprivation in Mice
05:05

Establishing a Device for Sleep Deprivation in Mice

Published on: September 22, 2023

Chronic Sleep Deprivation in Mouse Pups by Means of Gentle Handling
03:46

Chronic Sleep Deprivation in Mouse Pups by Means of Gentle Handling

Published on: October 11, 2018

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
06:23

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

Published on: September 22, 2020

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genomics

Background:

  • Sleep deprivation (SD) is linked to neuropsychiatric disorders, but its molecular basis is unclear.
  • Extended wakefulness increases neuronal activity, suggesting a potential link between SD and neuronal hyperexcitation.

Purpose of the Study:

  • To test if SD shares transcriptomic signatures with neuronal hyperexcitation.
  • To identify gene pathways and cell types involved in these shared signatures.

Main Methods:

  • Systematic comparison of publicly available transcriptomic datasets from SD and neuronal hyperexcitation models using the Running Fisher algorithm.
  • Analysis across multiple mouse brain regions and rodent models.
  • Single-cell transcriptomic analysis to identify enriched cell types.

Main Results:

  • Significant transcriptomic overlaps (73%) were found between SD and neuronal hyperexcitation models.
  • Shared signatures were enriched in pathways for neuronal plasticity, immune response, and inflammation.
  • Key genes included immediate early genes (IEGs) and inflammation-associated genes.
  • Microglia and neurons showed the strongest enrichment of shared signatures.

Conclusions:

  • SD is associated with a transcriptomic state similar to acute neuronal hyperexcitation.
  • Shared molecular pathways link sleep loss to processes implicated in neuropsychiatric disorders.
  • Neuronal hyperexcitation molecular processes may contribute to SD-induced brain dysfunction.