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High-performance surface plasmon resonance sensor utilizing AuNPs/Au nanocone array for ultrasensitive dopamine
Jian Shi1, Xiaomu Shan1, Hongren Wang1
1Shandong Provincial Key Laboratory of Light Field Manipulation Physics and Applications &School of Physics and Optoelectronics, Shandong Normal University, Jinan, 250358, China.
Mikrochimica Acta
|July 1, 2026
Summary
This study presents a novel optical fiber biosensor for detecting dopamine (DA). The ultrasensitive, label-free sensor utilizes gold nanocone arrays and gold nanoparticles for enhanced detection in clinical samples.
Area of Science:
- Nanotechnology
- Biomedical Engineering
- Analytical Chemistry
Background:
- Dopamine (DA) detection is crucial for diagnosing neurological disorders.
- Existing biosensing methods often lack the required sensitivity and selectivity.
- Optical fiber-based sensors offer potential for point-of-care diagnostics.
Purpose of the Study:
- To develop a high-performance optical fiber surface plasmon resonance (SPR) biosensor for ultrasensitive dopamine determination.
- To enhance sensor performance through novel nanostructure design and fabrication.
- To evaluate the sensor's applicability in complex biological matrices.
Main Methods:
- Fabrication of gold nanocone arrays using thermal nanoimprinting and gold sputtering.
- Immobilization of gold nanoparticles (AuNPs) via DNA assistance to create gap hotspots.
- Utilizing extraordinary optical transmission (EOT) and SPR-LSPR coupling for signal amplification.
- Finite element simulation to understand electromagnetic field enhancement.
Main Results:
- Achieved an ultra-low detection limit of 2.7 × 10-14 M for dopamine.
- Demonstrated significant improvements in sensitivity (37.4%) and figure of merit (FOM) (54.2%) compared to conventional gold films.
- Exhibited excellent selectivity and stability in serum, cerebrospinal fluid (CSF), and whole blood.
- Verified strong electromagnetic field enhancement through simulations and experiments.
Conclusions:
- The developed optical fiber SPR biosensor offers a robust and scalable platform for label-free dopamine detection.
- The sensor's ultrasensitive performance and stability in biological fluids make it suitable for clinical point-of-care applications.
- This technology holds promise for advancing early diagnosis and monitoring of neurological conditions.
