Multi-antigen-targeting T cells in pediatric central nervous system tumors: a phase 1 trial

Stephanie Gomez1,2, Rachel A DiCioccio1, Ashley E Geiger1

  • 1Children's National Hospital, Washington, DC, USA.

Nature Medicine
|July 1, 2026
PubMed
Summary

This study explored a new T-cell therapy for pediatric central nervous system (CNS) tumors. The treatment targeting WT1, PRAME, and survivin showed safety and feasibility, with some promising efficacy signals in children with CNS cancers.