Pregnancy and related complications in achondroplasia: a scoping review

Very few articles have investigated pregnancy in women with achondroplasia. A scoping review methodology was used to record and summarize the existing research evidence. The review process was conducted in accordance with the PRISMA-ScR guidelines. Original studies and case series mentioning achondroplasia with a minimum of 5 pregnancies were included. A total of 1527 articles were screened by title and abstract. Twenty-one full-text articles were reviewed for eligibility criteria. Seven studies were included. The reference details, study characteristics, topics of interest, and main findings are presented. The combination of short stature and a narrow pelvis led to a difficult antenatal and intrapartum period. Over the past decades, the number of publications on achondroplasia has increased overall, but pregnancy-related articles are still lacking. Multicentre studies should be initiated following methodological reference standards to strengthen the reliability and generalizability of the findings and to increase their relevance for implementation in clinical practice.