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MMRN1 suppresses thyroid cancer progression via activation of the Hippo signaling pathway

Meihua Zhang1, Junjun Guo2, Jun Sun3

  • 1Endoscopy Center, Qingdao Central Hospital, University of Health and Rehabilitation Sciences, Qingdao, Shandong, China.

Endocrine Research
|July 1, 2026
PubMed
Abstract

Insights

Multimerin 1 (MMRN1) suppresses thyroid cancer (TC) by activating the Hippo pathway and influencing oxidative stress and ferroptosis. This discovery presents MMRN1 as a promising therapeutic target for TC treatment.

Area of Science:

  • Endocrinology
  • Oncology
  • Molecular Biology

Background:

  • Thyroid cancer (TC) incidence is rising globally, making it the most common endocrine malignancy.
  • The role of Multimerin 1 (MMRN1) in TC is unknown, despite its involvement in other cancers.
  • The Hippo pathway is crucial for regulating cell growth and is often altered in TC.

Purpose of the Study:

  • To investigate the function of MMRN1 in thyroid cancer.
  • To determine if MMRN1 affects the Hippo signaling pathway in TC.
  • To explore MMRN1's impact on oxidative stress and ferroptosis in TC.

Main Methods:

  • Bioinformatics analysis identified differentially expressed genes in TC.
  • MMRN1 expression was confirmed in TC cell lines and normal cells using RT-qPCR and Western blot.
  • Functional assays, Hippo pathway activity assessments, and analysis of oxidative stress/ferroptosis markers were performed.

Main Results:

  • MMRN1 expression was found to be decreased in TC tissues and cell lines.
  • Overexpressing MMRN1 inhibited TC cell proliferation, migration, and invasion, while promoting apoptosis.
  • MMRN1 activated the Hippo pathway and modulated oxidative stress and ferroptosis markers, indicating increased sensitivity to ferroptosis.

Conclusions:

  • MMRN1 functions as a tumor suppressor in thyroid cancer.
  • MMRN1 exerts its effects by activating the Hippo pathway and influencing oxidative stress and ferroptosis.
  • MMRN1 represents a potential therapeutic target for managing thyroid cancer.
Keywords:
FerroptosisHippo pathwayMMRN1YAP/TAZoxidative stressthyroid cancer

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