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Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis
Published on: May 16, 2025
Pharmacotherapeutic interventions for pediatric ulcerative colitis.
Alessia Romano1, Giovanna Fernanda Vazzana2, Claudio Romano2
1Pediatric Unit, University Tor Vergata, Rome, Italy.
Pediatric ulcerative colitis (UC) management requires personalized treatment balancing efficacy and safety. Advanced therapies like biologics and precision medicine offer improved outcomes for children with UC.
Area of Science:
- Pediatric gastroenterology
- Immunology
- Pharmacology
Background:
- Pediatric ulcerative colitis (UC) is a chronic inflammatory colon disease impacting children's growth and quality of life.
- Effective therapeutic strategies are crucial for managing pediatric UC due to immune dysregulation.
Purpose of the Study:
- To review current and emerging pharmacologic treatments for pediatric UC.
- To discuss treatment mechanisms, efficacy, safety, and challenges in pediatric UC management.
Main Methods:
- Comprehensive literature search of PubMed, Embase, and Cochrane Library (1987-2026).
- Inclusion of 100 studies (67 pediatric, 33 adult), including RCTs, observational studies, systematic reviews, and guidelines.
Main Results:
- Overview of conventional (aminosalicylates, corticosteroids, immunomodulators) and advanced therapies (biologics, small molecules).
- Discussion of treatment efficacy, safety, challenges like inadequate response, and the need for precision medicine.
- Summary of emerging therapies and ongoing pediatric trials.
Conclusions:
- Personalized management balancing efficacy, safety, and long-term outcomes is essential for pediatric UC.
- Novel biologics, targeted therapies, and precision medicine strategies show promise for better disease control and quality of life.
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