Expert Clinical Consensus on Body Surface Gastric Mapping Phenotypes for Gastroduodenal Disorders: 'Auckland...

Area of Science:

• Gastroenterology
• Physiology
• Medical Diagnostics

Background:

• Chronic gastroduodenal disorders present management challenges.
• Novel diagnostic approaches are crucial for understanding causes and guiding therapy.
• Body Surface Gastric Mapping (BSGM) offers insights into gastric motor and sensory dysfunction.

Purpose of the Study:

• To establish the first consensus classification of BSGM phenotypes.
• To provide a structured framework for BSGM-defined patient phenotypes.
• To link BSGM phenotypes to mechanisms and evidence-based treatments.

Main Methods:

• Systematic literature and clinical database review.
• Synthesis of evidence from 50 studies in gastroparesis, chronic nausea/vomiting, and functional dyspepsia.
• Iterative consensus development by international clinical experts.

Main Results:

• Six BSGM phenotypes were endorsed: three myoelectrical (Dysrhythmic, High Frequency, Low Meal Response) and three symptom-based (Sensorimotor, Continuous, Delayed Onset Symptoms).
• Phenotypes were linked to mechanisms like interstitial cell of Cajal depletion, vagal impairment, and gut-brain dysregulation.
• Ten of eleven consensus statements achieved >80% agreement.

Conclusions:

• The Auckland Classification provides a structured framework for BSGM phenotypes.
• It suggests evidence and mechanism-based treatments for each phenotype.
• This classification supports research, validation, and clinical integration of BSGM.