Related Experiment Video
Updated: Jul 2, 2026
06:46
Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
Risk Factors for Positive Peritoneal Lavage Cytology in Stage I to III Colon Cancer: A Prospective Observational
Radha Raman Mondal1, Subrata Sahu2, Sudip Haldar3
1Department of Surgical Oncology, Medical College and Hospital, 88, College Street, Kolkata, 700073 India.
Indian Journal of Surgical Oncology
|July 1, 2026
Summary
Positive peritoneal lavage cytology (PLC) in colon cancer indicates higher recurrence risk. This study found PLC is linked to advanced stage, nodal involvement, and specific tumor features, but not tumor location.
Area of Science:
- Oncology
- Gastroenterology
- Surgical Pathology
Background:
- Positive peritoneal lavage cytology (PLC) in non-metastatic colon cancer is associated with increased risk of peritoneal recurrence and poorer survival.
- The relationship between PLC and clinicopathological factors like tumor site, stage, and other pathological variables requires further investigation.
Purpose of the Study:
- To investigate the association between positive PLC and tumor laterality, stage, and other pathological parameters in patients with resectable non-metastatic colon cancer.
Main Methods:
- A prospective, observational study was conducted on 119 patients with stage I-III colon adenocarcinoma undergoing curative resection.
- Peritoneal lavage cytology (PLC) was performed using standardized methods.
- Statistical analysis, including univariate and multivariate analyses, was used to assess correlations.
Main Results:
- Positive PLC was not significantly associated with tumor laterality (right-sided vs. left-sided).
- Univariate analysis showed positive PLC correlated with higher N-status, overall stage, perineural invasion (PNI), extranodal extension (ENE), signet ring cell morphology, and elevated CEA levels.
- Multivariate analysis identified associations between positive PLC and higher-grade disease, N-status, and stage IIIC disease.
Conclusions:
- Positive PLC in resectable colon cancer is not linked to primary tumor location but is associated with adverse pathological features.
- Findings suggest PLC may serve as a marker for more aggressive disease characteristics, warranting further research into its predictive value for peritoneal recurrence.
