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Association between psychopathology and neuropsychological dysfunction in patients with severe mental illness: A
M Farsana Banu1, Balaji Bharadwaj1, Bitty Raghavan2
1Department of Psychiatry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
Background:
Cognitive impairment is a core feature of schizophrenia and bipolar disorder (BD), yet few studies have explored its association with specific psychopathological symptoms.
Aim:
We aimed to analyse the relationship between psychotic symptoms and cognitive impairment using bedside cognitive tests in patients with schizophrenia and BD.
Methods:
This cross-sectional study included 100 patients (50 with schizophrenia and 50 with BD) from a tertiary care psychiatry department. Participants were selected based on inclusion and exclusion criteria and assessed using standardized psychopathology scales and cognitive tests.
Results:
Abstract thinking was more intact in BD (72%) than schizophrenia (30%) (P<0.05). Impairment was associated with delusions and hallucinations. Patients with schizophrenia showed poorer semantic fluency than those with BD (P=0.01). Delusions were linked to reduced semantic fluency, while auditory hallucinations were associated with poorer verbal memory and concentration.
Conclusion:
Specific cognitive deficits are associated with psychopathology, suggesting shared neurobiological mechanisms and potential clinical markers.
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