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Related Concept Videos

Analysis of Population Pharmacokinetic Data01:12

Analysis of Population Pharmacokinetic Data

Analysis of population pharmacokinetic data involves studying the behavior of drugs within diverse populations to understand their pharmacokinetic parameters. Traditional pharmacokinetic methods typically involve collecting samples from a few individuals and estimating these parameters. While these methods are commonly used, they have limitations in capturing the variability in drug response among individuals or heterogeneous populations. Population pharmacokinetics is employed to address these...
Pharmacodynamic Models: Additive and Proportional Drug Effect Model01:09

Pharmacodynamic Models: Additive and Proportional Drug Effect Model

Drug response models describe how pharmacological agents interact with biological systems to produce measurable effects. Baseline responses are inherent physiological activities without a drug significantly influencing the observed pharmacological outcomes. Depending on the drug response model employed, these baseline responses may combine with the drug's effect in either an additive or proportional manner.Additive Drug Response ModelIn the additive model, the drug effect is independent of the...
Drug Control Governance: Regulatory Bodies and Their Impact01:03

Drug Control Governance: Regulatory Bodies and Their Impact

Drug control governance involves the oversight and regulation of pharmaceuticals to ensure their safety and efficacy while preventing illegal drug use and trafficking. Regulatory bodies, including the US Food and Drug Administration (FDA) and the European Union's European Medicines Agency (EMA), play a central role in this process. These agencies evaluate the safety and efficacy of drugs before they can be marketed. They fund clinical trials and assess the benefits and risks associated with a...
Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions01:15

Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions

PK–PD modeling has significantly influenced FDA regulatory decisions, particularly drug approval, dosage optimization, and labeling. These models integrate pharmacokinetics (PK) and pharmacodynamics (PD) to predict drug behavior and effects, aiding in optimizing dosing regimens and enhancing the probability of clinical trial success.One notable example is Nesiritide (Natrecor®), a recombinant human brain natriuretic peptide for treating acute decompensated congestive heart failure (CHF).
Model Approaches for Pharmacokinetic Data: Physiological Models01:15

Model Approaches for Pharmacokinetic Data: Physiological Models

Physiological models in pharmacokinetics are instrumental in understanding the distribution and elimination of drugs within the body. These models describe the drug concentration within target organs, influenced by factors such as drug uptake, tissue volume, and blood flow. Drug uptake is governed by the partition coefficient, which signifies the drug concentration ratio in tissue to that in the blood. The blood flow rate to a specific tissue is expressed as Qt, and the rate of change in tissue...
Pharmacodynamic Models: Overview01:27

Pharmacodynamic Models: Overview

Pharmacodynamic (PD) responses describe the interaction between a drug and its biological target, culminating in a physiological effect. These responses can be classified into different types: continuous variables, such as blood glucose levels; categorical outcomes, like survival rates; and time-to-event metrics, such as disease progression. Understanding and modeling PD responses are critical for optimizing drug efficacy and safety.PD models describe the relationship between drug concentration...

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Related Experiment Video

Updated: Jul 2, 2026

An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings
19:57

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Published on: March 30, 2014

Job Strain Profiles in Pharmacy Workforce: Evidence from the Job Demand, Control, and Support Model in Ghana.

Godwin Dogbey1, Adriana-Maria Hiller2,3, Awaanu-Lah Zinale1

  • 1School of Veterinary Sciences, University for Development Studies, Nyankpala, Ghana.

Safety and Health at Work
|July 1, 2026
PubMed
Summary

Psychosocial work factors like job demand, control, and support impact Ghanaian pharmacy staff. Job title, age, and experience influence these factors, highlighting the need for targeted stress-reduction interventions.

Keywords:
GhanaHealthJob Demand–Control–Support (JD-C-S) modelPharmacy personnel

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Last Updated: Jul 2, 2026

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19:57

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Published on: March 30, 2014

Area of Science:

  • Occupational Health
  • Psychosocial Work Environment
  • Healthcare Workforce Studies

Background:

  • The Job Demand-Control-Support (JD-C-S) model is a framework for understanding how work environment factors influence employee health and performance.
  • Psychosocial factors at work are critical determinants of well-being and productivity in healthcare settings.

Purpose of the Study:

  • To investigate how demographic characteristics, job titles, and professional experience correlate with job demand, control, and support among pharmacy personnel in Ghana.
  • To identify specific subgroups within the pharmacy workforce that may be at higher risk for job strain.

Main Methods:

  • A cross-sectional survey utilizing the JD-C-S questionnaire was administered to pharmacy staff in Tamale and Sagnarigu, Ghana.
  • Job demand and control scores were dichotomized using median cutoffs and categorized into four job-strain classifications (high-strain, low-strain, active, passive).
  • Logistic and linear regression analyses were employed to examine associations between job strain categories and demographic/professional variables, with sensitivity analyses conducted.

Main Results:

  • The study included 117 pharmacy personnel, with passive (43.6%) and active (29.1%) job types being most prevalent.
  • Younger participants (≤30 years) reported significantly higher job demand and control compared to older counterparts.
  • Medicine counter assistants demonstrated a higher likelihood of experiencing high-strain jobs (OR: 2.80) and lower job control (β: -0.38) compared to pharmacists.

Conclusions:

  • Demographic factors such as age and job title significantly shape the psychosocial work profiles of pharmacy staff.
  • Findings underscore the necessity for tailored interventions to mitigate workplace stress and enhance the overall well-being of pharmacy personnel.