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Impact of Dysplasia on Inverted Papilloma Recurrence: A Systematic Review and Meta-Analysis
Peter Giannaris1,2,3, Tristan Tham4, Eric Giannaris3
1Northwell Health, New Hyde Park, New York, USA.
International Forum of Allergy & Rhinology
|July 1, 2026
Summary
Dysplasia significantly increases the risk of recurrence in sinonasal inverted papilloma (SNIP). Patients with dysplasia have over three times the odds of SNIP recurrence, highlighting the need for improved risk stratification.
Area of Science:
- Otolaryngology
- Oncology
- Pathology
Background:
- Sinonasal inverted papilloma (SNIP) is a benign tumor known for local aggressiveness and recurrence.
- While various factors influence SNIP recurrence, the prognostic significance of dysplasia remains unclear.
- Clarifying dysplasia's role is crucial for improving postoperative risk stratification in SNIP management.
Purpose of the Study:
- To systematically review and meta-analyze the existing literature on dysplasia as a predictor of recurrence in SNIP.
- To quantify the association between dysplasia and SNIP recurrence risk.
Main Methods:
- A systematic review and meta-analysis adhering to PRISMA guidelines.
- Searched PubMed, Embase, Scopus, and Web of Science for studies reporting SNIP recurrence stratified by dysplasia.
- Performed fixed-effects meta-analysis to calculate pooled odds ratios (OR) for recurrence in patients with and without dysplasia.
Main Results:
- Included 13 studies with 1893 patients; mean age 48.3-58.0 years, predominantly male (68.1%).
- Dysplasia was present in 283 patients, with a recurrence rate of 36.7% compared to 22.4% in 1346 patients without dysplasia.
- Dysplasia significantly increased recurrence odds (pooled OR 3.42; 95% CI, 2.45-4.78), with low heterogeneity (I² = 20.33%).
Conclusions:
- Dysplasia is a significant independent predictor of SNIP recurrence.
- Patients with dysplasia face 3.4 times higher odds of recurrence.
- Standardized dysplasia reporting and risk stratification are essential for optimizing SNIP surveillance.
