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Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
Eosinophilic Esophagitis and Autoimmune Thyroid Disease: A Population-Based Matched Cohort Study
Soran R Bozorg1,2, David Bergman1, Fahim Ebrahimi1,3
1Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden.
United European Gastroenterology Journal
|July 1, 2026
Summary
Eosinophilic esophagitis (EoE) is linked to prior autoimmune thyroid disease (AITD), especially in children. While future AITD risk is not elevated in general EoE patients, it is in childhood-onset cases, warranting physician vigilance.
Area of Science:
- Gastroenterology
- Immunology
- Endocrinology
Background:
- Eosinophilic esophagitis (EoE) is an immune-mediated esophageal disease.
- Previous studies suggest a potential link between EoE and autoimmune thyroid disease (AITD), but this association requires further investigation.
Purpose of the Study:
- To investigate the association between EoE and autoimmune thyroid disease (AITD).
- To examine the risk of prior and future AITD in patients with EoE, with a focus on childhood-onset EoE.
Main Methods:
- Utilized the nationwide ESPRESSO cohort in Sweden (2006-2023) with biopsy-confirmed EoE.
- Compared EoE patients to general population and sibling references matched for key demographics.
- Employed Cox proportional hazard and logistic regression models to assess future and prior AITD risks, respectively.
Main Results:
- EoE patients showed a higher prevalence of prior AITD (OR 1.29) compared to references.
- No significant association was found between EoE and future AITD in the overall cohort (HR 1.18).
- Childhood-onset EoE demonstrated a significantly increased risk for both prior (OR 4.71) and future AITD (HR 2.53).
Conclusions:
- Eosinophilic esophagitis is associated with a history of autoimmune thyroid disease.
- Physicians should monitor for AITD symptoms in EoE patients, particularly those with childhood-onset disease.
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