Related Experiment Videos

Cognitive assessment in children with intestinal failure on and weaned off parenteral nutrition

Rozemarijn A L Duister1, Lotte E Vlug1, Marjolein Spoel1

  • 1Department of Pediatrics, Division of Gastroenterology, Erasmus MC Sophia Children's Hospital, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Journal of Pediatric Gastroenterology and Nutrition
|July 1, 2026
PubMed

Insights

Children with intestinal failure (IF) have average intelligence but are at risk for below-average IQ. Factors like line infections correlated with IQ, but none were significant in regression analysis.

Area of Science:

  • Pediatric Gastroenterology
  • Neurodevelopmental Pediatrics
  • Clinical Nutrition

Background:

  • Children with intestinal failure (IF) face risks for cognitive impairments.
  • Assessing intelligence quotient (IQ) and associated factors is crucial for this vulnerable population.

Purpose of the Study:

  • To evaluate intelligence quotient (IQ) outcomes in children with intestinal failure (IF).
  • To identify factors associated with cognitive outcomes in children with IF.

Main Methods:

  • A multicenter international cross-sectional study involving children with IF.
  • IQ was assessed using standardized Wechsler scales (WPPSI-III, WISC-V, WAIS-IV).
  • Correlations and linear regression analyses were used to identify factors associated with IQ.

Main Results:

  • Fifty children with IF were included; 30% had very/extremely low IQ scores, significantly differing from the general population.
  • Parental education, line infections, and hospital admission duration showed correlations with IQ.
  • No factors remained statistically significant after multiple linear regression analysis.

Conclusions:

  • Children with IF generally have average IQ but are at increased risk for below-average cognitive outcomes.
  • While several factors correlate with IQ, their significance diminishes in multivariate analysis, highlighting the complexity of cognitive development in IF.
Abstract

Keywords:
artificial feedingcognitionpaediatricsshort bowel syndrome

Related Concept Videos

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Assessment of the Gastrointestinal System II: Health Perception Pattern01:29

Assessment of the Gastrointestinal System II: Health Perception Pattern

Assessing the gastrointestinal (GI) system is a complex process that begins with collecting subjective data. This data, collected through patient interviews, provides crucial insights into the patient's health history, perception patterns, and lifestyle habits, all contributing significantly to GI health.
Health Perception Patterns
Health perception patterns offer valuable insights into a patient's lifestyle habits and how they may impact their GI health. These patterns include:
Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding01:15

Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding

Enteral nutrition encompasses various methods of delivering nutrition directly to the gastrointestinal (GI) tract, bypassing traditional oral intake. It is particularly beneficial for patients who cannot eat by mouth but have a functioning digestive system. Key methods include nasointestinal feeding, gastrostomy, and jejunostomy, each suited to different clinical scenarios based on the patient's needs and condition.
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube through...
Assessment of the Gastrointestinal System I: Subjective Data01:17

Assessment of the Gastrointestinal System I: Subjective Data

Assessing the gastrointestinal (GI) system is a complex process that begins with collecting subjective data. This data, collected through patient interviews, provides crucial insights into the patient's health history, perception patterns, and lifestyle habits, all contributing significantly to GI health.
Health History
The initial step in assessing the GI system is obtaining a comprehensive health history. This includes inquiring about the patient's history or presence of problems related to...
Assessment of the Rectum and Anus01:25

Assessment of the Rectum and Anus

Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
Irritable Bowel Syndrome III: Medical and Nursing Management01:30

Irritable Bowel Syndrome III: Medical and Nursing Management

Managing Irritable Bowel Syndrome (IBS) involves a multifaceted approach, including lifestyle modifications, dietary changes, and medication.