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Related Experiment Video

Updated: Jul 2, 2026

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
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Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

Zein-Ceria Hybrid Microparticles Enable Long-Term ROS-Scavenging Oxygenation for Osteogenic Microtissues Engineering.

Hayeon Byun1, Seok Gyu Han1, Niels Willemen2

  • 1Division of Engineering in Medicine, Department of Medicine, Harvard Medical School, and Brigham and Women's Hospital, Cambridge, Massachusetts, USA.

Advanced Materials (Deerfield Beach, Fla.)
|July 1, 2026
PubMed
Summary

This study introduces a novel zein-ceria microparticle for sustained oxygen release and reactive oxygen species (ROS) scavenging, improving cell survival and bone regeneration in oxygen-deprived environments.

Keywords:
ceriaosteogenesisosteoinductive factoroxygenating micromaterialsregenerative medicinezein

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Last Updated: Jul 2, 2026

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Published on: August 26, 2018

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Tissue regeneration is hindered by oxygen-deprived microenvironments, limiting cell survival and function.
  • Conventional oxygen-releasing materials cause burst release, oxidative stress, and lack bioactive factors.

Purpose of the Study:

  • To develop a microparticle for sustained, ROS-neutral oxygenation and bioactive factor delivery.
  • To enhance cell survival and promote bone regeneration in challenging microenvironments.

Main Methods:

  • Engineered a zein-ceria hybrid microparticle with a hydrophobic zein core and a ceria nanozyme shell.
  • Integrated microparticles into stem cell spheroids for enhanced anoxia survival.
  • Utilized biofunctional surface for protein immobilization and osteogenesis induction.
  • Tested efficacy in a mouse calvarial defect model.

Main Results:

  • Achieved sustained oxygenation for over 40 days with controlled release.
  • Demonstrated continuous reactive oxygen species (ROS) scavenging via ceria nanozyme.
  • Enhanced stem cell survival under anoxia and promoted spontaneous osteogenesis.
  • Accelerated bone regeneration in a mouse calvarial defect model.

Conclusions:

  • The zein-ceria microparticle provides sustained, ROS-neutral oxygenation and delivers osteoinductive factors.
  • This modular platform enhances cell survival and bone regeneration in oxygen-deprived conditions.
  • The design offers a versatile approach for developing advanced biomaterials in regenerative medicine.