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Fifty years of SSRI-related oral side effects: A call for interprofessional collaboration
Frank Lobbezoo1,2, Anne-Fleur Helene Lobbezoo3, Pauline Marie-Julie Lobbezoo4
1Department of Orofacial Pain and Dysfunction, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and the Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Abstract:
The oral side effects of selective serotonin reuptake inhibitors (SSRIs) include xerostomia, gingival bleeding, burning mouth syndrome, bruxism, and temporomandibular disorders (TMD), impacting the quality of life (QoL). These stomatognathic diseases are often overlooked in clinical practice. This comment advocates interprofessional relations among physicians, pharmacists and dentists to improve the recognition, prevention and management of SSRI-related oral side effects.
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Pharmacovigilance
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
