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Triglyceride-glucose index is independently associated with left ventricular outflow tract obstruction in

Tolga Kunak1, Özkan Kayhan2, Ayşegül Ülgen Kunak3

  • 1Department of Cardiology, Akdeniz University Faculty of Medicine, Antalya, Türkiye.

Biomolecules & Biomedicine
|July 1, 2026
PubMed

Insights

The triglyceride-glucose (TyG) index, a marker for insulin resistance, is independently associated with left ventricular outflow tract (LVOT) obstruction in hypertrophic cardiomyopathy (HCM) patients. Higher TyG index values correlate with obstructive HCM, suggesting a link between metabolic health and disease severity.

Area of Science:

  • Cardiology
  • Metabolic Syndrome
  • Cardiovascular Research

Background:

  • Insulin resistance and metabolic dysregulation contribute to myocardial remodeling in hypertrophic cardiomyopathy (HCM).
  • The triglyceride-glucose (TyG) index is a surrogate marker for insulin resistance.
  • The association between the TyG index and left ventricular outflow tract (LVOT) obstruction in HCM is not well understood.

Purpose of the Study:

  • To investigate the association between the TyG index and LVOT obstruction in adult HCM patients.
  • To determine if the TyG index can predict or correlate with LVOT obstruction severity.

Main Methods:

  • Retrospective observational study of 124 adult HCM patients.
  • Calculation of TyG index from fasting triglyceride and glucose levels.
  • Multivariable logistic regression and ROC curve analysis to assess association and discriminatory performance.

Main Results:

  • Patients with obstructive HCM had significantly higher TyG index values (9.07 ± 0.25) than non-obstructive HCM patients (8.76 ± 0.21).
  • The TyG index showed an independent association with LVOT obstruction (OR 1.84 per 0.1-unit increase).
  • TyG index demonstrated moderate correlations with resting (r=0.519) and provoked (r=0.557) LVOT gradients, with good discriminatory performance (AUC: 0.826).

Conclusions:

  • The TyG index is independently associated with LVOT obstruction in HCM patients.
  • Higher TyG index values are linked to the obstructive phenotype in HCM.
  • The TyG index may offer complementary clinical insights into metabolic status and disease manifestation in HCM, warranting further investigation.

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