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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
[Antibiotic stewardship in urology : Time to rethink?]
Fabian P Stangl1, Giuseppe Magistro2
1Klinik und Poliklinik für Urologie und Kinderurologie, Universitätsklinikum Würzburg, Julius-Maximilians-Universität Würzburg, Würzburg, Deutschland.
Urologie (Heidelberg, Germany)
|July 1, 2026
Summary
Antibiotic stewardship (ABS) is crucial for rational antibiotic use in urological infections to combat multidrug-resistant pathogens. This article provides practical ABS recommendations for urologists, addressing guideline adherence and common misuse, particularly with fluoroquinolones.
Area of Science:
- Urology
- Infectious Diseases
- Pharmacology
Background:
- Urological infections are common bacterial diseases leading to high antibiotic use.
- This contributes to the increased risk of multidrug-resistant pathogens.
- Antibiotic stewardship (ABS) is vital for rational antibiotic use.
Purpose of the Study:
- To illustrate the principles of antibiotic stewardship (ABS) based on current guidelines for urological infections.
- To describe frequent misapplications of antibiotics in urological practice.
- To provide practical recommendations for urologists regarding antibiotic use in urinary tract infections and urological interventions.
Main Methods:
- Review of current European and German guidelines on urological infections.
- Analysis of common suboptimal antibiotic prescribing practices.
- Development of practical recommendations for urologists.
Main Results:
- Antibiotic use in urology is often suboptimal, particularly for asymptomatic bacteriuria and excessive fluoroquinolone use.
- Clear guideline recommendations for ABS exist but are not consistently followed.
- Frequent misapplications of antibiotics are identified.
Conclusions:
- Adherence to antibiotic stewardship principles is essential for managing urological infections and preventing antimicrobial resistance.
- Urologists require practical guidance to optimize antibiotic prescribing and avoid common errors.
- Implementing ABS strategies can improve patient outcomes and reduce the burden of multidrug-resistant infections.
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