Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Bioavailability Study Design: Healthy Subjects Versus Patients01:15

Bioavailability Study Design: Healthy Subjects Versus Patients

Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
Preclinical Development: Overview01:28

Preclinical Development: Overview

Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

External Validation of Published Scoring Systems to Predict Incident Atrial Fibrillation After Cryptogenic Stroke/Embolic Stroke of Undetermined Source.

Journal of the American Heart Association·2026
Same author

Baseline characteristics of patients enrolled in the AZIMUTH trial: an e-health-integrated, smartphone app-based model of care for heart failure patients.

European heart journal open·2026
Same author

GLP-1 Receptor Agonists and Primary Prevention of Cancer Therapy-Related Cardiac Dysfunction.

The American journal of cardiology·2026
Same author

Hybrid Surgical-Catheter Epicardial Ablation of Ventricular Tachycardia: A Case Series.

Journal of clinical medicine·2026
Same author

Near-field substrate analysis in ventricular tachycardia: a novel approach to identify the critical isthmus.

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing·2026
Same author

Artificial Intelligence to Predict Major Arrhythmic Events Based on Left Ventricular Electroanatomic Mapping Data.

Journal of clinical medicine·2026
Same journal

Acute and Chronic Myocarditis in Men and Women.

Current heart failure reports·2026
Same journal

Smart Technology, Fragile Hearts: Navigating AI's Challenges and Limitations in Heart Failure Management.

Current heart failure reports·2026
Same journal

Palliative Care in Advanced Heart Failure.

Current heart failure reports·2026
Same journal

The Evolving Utility of Artificial Intelligence-Based Tools for the Detection of Heart Failure and Cardiomyopathies: From Potential to Implementation.

Current heart failure reports·2026
Same journal

Emerging Artificial Intelligence Tools for the Screening of Structural and Valvular Heart Disease.

Current heart failure reports·2026
Same journal

Advances in Living Myocardial Slice Technology for Heart Failure Research.

Current heart failure reports·2026
See all related articles

Related Experiment Video

Updated: Jul 2, 2026

Percutaneous Contrast Echocardiography-guided Intramyocardial Injection and Cell Delivery in a Large Preclinical Model
14:24

Percutaneous Contrast Echocardiography-guided Intramyocardial Injection and Cell Delivery in a Large Preclinical Model

Published on: January 21, 2018

From Cardioprotection to Trial Design: Rethinking Cardiac Safety in Oncology.

Antonio Iaconelli1,2, Roberto Scacciavillani3, Lorenzo Cacioli3

  • 1Department of Cardiovascular Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, L.Go A. Gemelli, 1, 00168, Rome, Italy. iaconelli.antonio88@gmail.com.

Current Heart Failure Reports
|July 1, 2026
PubMed
Summary
This summary is machine-generated.

Preventing cancer therapy-related cardiac dysfunction shows modest benefits, mainly in subclinical changes. Standardized monitoring and broader patient inclusion are crucial for meaningful clinical outcomes in cardio-oncology research.

Keywords:
Artificial intelligenceCancer therapy–related cardiac dysfunctionCardio-oncologyCardiotoxicityCardiovascular prevention

More Related Videos

Hybrid Cell Analysis System to Assess Structural and Contractile Changes of Human iPSC-Derived Cardiomyocytes for Preclinical Cardiac Risk Evaluation
08:03

Hybrid Cell Analysis System to Assess Structural and Contractile Changes of Human iPSC-Derived Cardiomyocytes for Preclinical Cardiac Risk Evaluation

Published on: October 20, 2022

Slicing and Culturing Pig Hearts under Physiological Conditions
07:54

Slicing and Culturing Pig Hearts under Physiological Conditions

Published on: March 20, 2020

Related Experiment Videos

Last Updated: Jul 2, 2026

Percutaneous Contrast Echocardiography-guided Intramyocardial Injection and Cell Delivery in a Large Preclinical Model
14:24

Percutaneous Contrast Echocardiography-guided Intramyocardial Injection and Cell Delivery in a Large Preclinical Model

Published on: January 21, 2018

Hybrid Cell Analysis System to Assess Structural and Contractile Changes of Human iPSC-Derived Cardiomyocytes for Preclinical Cardiac Risk Evaluation
08:03

Hybrid Cell Analysis System to Assess Structural and Contractile Changes of Human iPSC-Derived Cardiomyocytes for Preclinical Cardiac Risk Evaluation

Published on: October 20, 2022

Slicing and Culturing Pig Hearts under Physiological Conditions
07:54

Slicing and Culturing Pig Hearts under Physiological Conditions

Published on: March 20, 2020

Area of Science:

  • Cardio-oncology
  • Cardiovascular Medicine
  • Oncology

Background:

  • Cardio-oncology addresses cardiovascular health during cancer treatment.
  • Evidence for preventing treatment-related cardiac injury is fragmented.
  • Standardized safety assessment is lacking.

Purpose of the Study:

  • Critically appraise randomized controlled trials (RCTs) on interventions for cancer therapy-related cardiac dysfunction.
  • Examine cardiovascular event monitoring, definition, and reporting in oncology trials.
  • Emphasize patient selection and surveillance protocols in clinical trials.

Main Methods:

  • Systematic review of RCTs on pharmacological and non-pharmacological interventions.
  • Analysis of cardiovascular event reporting in major oncology trials.
  • Evaluation of patient selection criteria and surveillance protocols.

Main Results:

  • Interventions show modest, inconsistent benefits, primarily affecting subclinical cardiac parameters.
  • Limited evidence exists for reducing overt heart failure, treatment interruptions, or cardiovascular mortality.
  • Oncology trials often have heterogeneous event definitions, incomplete safety reporting, and exclude patients with pre-existing cardiac disease.

Conclusions:

  • Individualized, risk-stratified prevention strategies targeting clinically relevant endpoints are needed.
  • Broader inclusion of patients with stable cardiovascular comorbidities and structured specialist supervision is essential.
  • Standardized cardiovascular safety monitoring, reporting, and AI-driven tools are critical for early detection and management of cardiotoxicity.