Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of fluid...
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identifying Contextual Barriers and Potential Solutions to Improving Hypertension Management in Rural Communities in the United States: Qualitative Study From 2 North Carolina Counties.

Journal of the American Heart Association·2026
Same author

Albuminuria and heart failure.

European heart journal·2026
Same author

Hypertension Disparities in Immigrant and Refugee Populations: Screening, Treatment Access, and Cultural Barriers.

Current hypertension reports·2026
Same author

Cardiovascular Disease Risk Factors of Syrian Refugees at the Zaatari Camp.

Circulation. Population health and outcomes·2026
Same author

Effectiveness of Multicomponent Interventions in Slowing Progression of CKD Stages G3-G4: A Systematic Review and Meta-Analysis.

Clinical journal of the American Society of Nephrology : CJASN·2026
Same author

Associations Among Digital Health Literacy, Lifestyle Factors, and Cardiovascular Health in Black and Hispanic Communities: Cross-Sectional Study.

Journal of medical Internet research·2025

Related Experiment Video

Updated: Jul 3, 2026

Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis
07:51

Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis

Published on: September 26, 2018

From Risk Determinants to Clinical Action: Understanding and Implementing the Cardiovascular Kidney Metabolic

Tazeen H Jafar1,2,3, Anqi Zhu1, Oluwabunmi Ogungbe4,5

  • 1Program in Health Services Research and Population Health, Duke-NUS Medical School, Singapore, Singapore.

Clinical Journal of the American Society of Nephrology : CJASN
|July 1, 2026
PubMed
Summary

Cardiovascular-kidney-metabolic (CKM) syndrome is a growing global health issue. This review synthesizes evidence on CKM syndrome, emphasizing integrated care and addressing social determinants of health for better outcomes.

Related Experiment Videos

Last Updated: Jul 3, 2026

Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis
07:51

Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis

Published on: September 26, 2018

Area of Science:

  • Cardiology
  • Nephrology
  • Endocrinology
  • Public Health

Background:

  • Cardiovascular-kidney-metabolic (CKM) syndrome represents a significant and escalating global health challenge.
  • It disproportionately affects socioeconomically disadvantaged populations, reflecting the intricate links between cardiovascular disease, chronic kidney disease, and metabolic dysfunction.
  • Key drivers include excess adiposity, insulin resistance, inflammation, and vascular dysfunction.

Purpose of the Study:

  • To review the development and progression of CKM syndrome.
  • To highlight the roles of biological mechanisms, shared risk factors, and social determinants of health (SDOH) in its pathophysiology.
  • To summarize the CKM health framework and discuss integrated care strategies.

Main Methods:

  • A comprehensive synthesis of current scientific evidence on CKM syndrome.
  • Analysis of the American Heart Association's CKM syndrome and health frameworks.
  • Review of integrated cardio-kidney-metabolic care principles from major professional societies.

Main Results:

  • CKM syndrome involves a progressive continuum of risk, from stage 0 to 4.
  • Effective management requires a multidisciplinary approach combining lifestyle interventions and pharmacotherapies.
  • Addressing biological mechanisms, shared risk factors, and SDOH is crucial for mitigating CKM syndrome.

Conclusions:

  • Integrated CKM care, aligned with guidelines from AHA, ASN, KDIGO, and ADA, is essential.
  • Practical strategies for integrating CKM care into routine practice are needed for feasibility and sustainability.
  • Future efforts should focus on developing CKM clinical practice and public health guidelines to reduce morbidity and mortality.