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An Ultra-Lightweight Cross-scale Attention Mamba Network for Accurate Skin Lesion Segmentation
IEEE Journal of Biomedical and Health Informatics
|July 1, 2026
Summary
The Cross-scale Attention Mamba Network (UCA-MNet) offers accurate skin lesion segmentation with significantly reduced computational needs. This deep learning model achieves high precision, enabling practical deployment in resource-limited environments for early skin cancer detection.
Area of Science:
- Medical Image Analysis
- Deep Learning
- Computer Vision
Background:
- Accurate skin lesion segmentation is crucial for early skin cancer detection and management.
- Current deep learning models face a trade-off between computational cost and accuracy, limiting their use in resource-constrained settings.
- Advanced segmentation models often introduce complexity, hindering practical application.
Purpose of the Study:
- To develop a computationally efficient yet accurate deep learning model for skin lesion segmentation.
- To address the limitations of existing models in terms of computational requirements and practical deployment.
- To introduce the Cross-scale Attention Mamba Network (UCA-MNet) for improved medical image segmentation.
Main Methods:
- Developed the Cross-scale Attention Mamba Network (UCA-MNet), a hierarchical encoder-decoder architecture.
- Integrated a Multi-Scale Module (MSM) utilizing a bidirectional Mamba (Bi-Mamba) for linear-complexity long-range dependency modeling.
- Employed Cross-Scale Attention (CSA) and Pyramidal Squeeze Attention (PSA) to capture both local textures and global context.
Main Results:
- UCA-MNet achieved high performance on ISIC-2017, ISIC-2018, and PH² benchmarks with F1 scores of 0.8254, 0.8814, and 0.9202, respectively.
- The model demonstrated significantly reduced computational requirements, using only 0.33 million parameters and 4.3 GFLOPs.
- UCA-MNet is approximately 83 times smaller than the leading VM-UNET model while maintaining competitive accuracy.
Conclusions:
- UCA-MNet effectively segments skin lesions with significantly lower computational demands.
- The model's efficiency supports deployment in resource-limited environments for medical image analysis.
- This research facilitates the practical application of deep learning for early skin cancer detection.

