Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 3, 2026

Multimodal Optical Imaging Platform for Studying Cellular Metabolism
04:47

Multimodal Optical Imaging Platform for Studying Cellular Metabolism

Published on: June 6, 2025

Illuminating aging with multimodal optical metabolic imaging.

Yajuan Li1, Erick Alvarado1, Zhi Li1

  • 1Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA 92093, USA.

Science Advances
|July 1, 2026
PubMed
Summary

Metabolic imaging visualizes aging

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Notch Signaling Reprograms Glial Lipid Metabolism to Promote Hypoxia Resistance.

bioRxiv : the preprint server for biology·2026
Same author

Multiscale metabolic mapping of lung tissue via coregistered mass spectrometry and nonlinear optical imaging.

Science advances·2026
Same author

Regional and Systemic Metabolic Remodeling Promotes Longevity by Bioengineered Yeast-Derived Lipids.

bioRxiv : the preprint server for biology·2026
Same author

Label free multimodal optical imaging of metabolic heterogeneity in aging by integrating SRS, MPF, FLIM, and SHG.

bioRxiv : the preprint server for biology·2026
Same author

Human Lymph Node Cellular Senescence Atlas Reveals Age-Dependent Alteration in Germinal Center B Cell Function and Niches.

bioRxiv : the preprint server for biology·2026
Same author

NetTracer3D Enables User-Friendly Analysis of Diverse Microscopic and Medical 3D Datasets.

bioRxiv : the preprint server for biology·2026

Area of Science:

  • Metabolomics
  • Aging Biology
  • Biomedical Imaging

Background:

  • Aging involves complex metabolic pathway reprogramming.
  • Visualizing metabolic changes in aging is challenging.
  • Metabolic imaging offers new insights into aging mechanisms.

Purpose of the Study:

  • To review advances in metabolic imaging for aging research.
  • To highlight multimodal nonlinear optical imaging techniques.
  • To discuss applications across diverse aging models.

Main Methods:

  • Multimodal nonlinear optical imaging.
  • Spatially resolved visualization of metabolic dynamics.
  • Label-free detection of metabolic shifts in vivo.

More Related Videos

Autofluorescence Imaging to Evaluate Cellular Metabolism
07:36

Autofluorescence Imaging to Evaluate Cellular Metabolism

Published on: November 15, 2021

Bioorthogonal Chemical Imaging of Cell Metabolism Regulated by Aromatic Amino Acids
10:42

Bioorthogonal Chemical Imaging of Cell Metabolism Regulated by Aromatic Amino Acids

Published on: May 12, 2023

Related Experiment Videos

Last Updated: Jul 3, 2026

Multimodal Optical Imaging Platform for Studying Cellular Metabolism
04:47

Multimodal Optical Imaging Platform for Studying Cellular Metabolism

Published on: June 6, 2025

Autofluorescence Imaging to Evaluate Cellular Metabolism
07:36

Autofluorescence Imaging to Evaluate Cellular Metabolism

Published on: November 15, 2021

Bioorthogonal Chemical Imaging of Cell Metabolism Regulated by Aromatic Amino Acids
10:42

Bioorthogonal Chemical Imaging of Cell Metabolism Regulated by Aromatic Amino Acids

Published on: May 12, 2023

Main Results:

  • Optical metabolic imaging captures organelle-level to tissue-scale metabolic alterations.
  • Techniques provide unique insights into aging mechanisms.
  • Label-free in vivo detection of early metabolic shifts is possible.

Conclusions:

  • Optical metabolic imaging is a powerful tool for aging research.
  • It offers potential for clinical translation in precision medicine.
  • It can enhance diagnosis, monitoring, and evaluation of aging processes.