Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Rheumatic Heart Disease I: Introduction

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...

Degenerative Disc Disease ll: Pathophysiology

Degenerative Disc Disease ll: Pathophysiology

The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Prologue: 2020 Annual Meeting of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA).

The Journal of rheumatology·2021

Same author

European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) SLE classification criteria item performance.

Annals of the rheumatic diseases·2021

Same author

Incidence of and Risk Factors for Heart Failure in Patients With Psoriatic Disease: A Cohort Study.

Arthritis care & research·2021

Same author

Lower vitamin D is associated with metabolic syndrome and insulin resistance in systemic lupus: data from an international inception cohort.

Rheumatology (Oxford, England)·2021

Same author

Systematic literature review of non-topical treatments for early, untreated (systemic therapy naïve) psoriatic disease: a GRAPPA initiative.

Rheumatology advances in practice·2021

Same author

The baseline interferon signature predicts disease severity over the subsequent 5 years in systemic lupus erythematosus.

Arthritis research & therapy·2021

Search research articles

Related Experiment Video

Updated: Jul 3, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Radiographic sacroiliitis progression in psoriatic arthritis.

Virginia Carrizo Abarza^1,2, Pankti Mehta^1,2,3, Fadi Kharouf^1,2,4

¹Gladman Krembil Psoriatic Arthritis Program, Centre for Prognosis Studies in the Rheumatic Diseases, Schroeder Arthritis Institute, University Health Network, Toronto, ON, Canada.

Rheumatology (Oxford, England)

|July 1, 2026

Summary

Radiographic sacroiliitis progression is common in psoriatic arthritis (PsA). Increased inflammation drives risk, but biologic/targeted synthetic disease-modifying antirheumatic drug (b/tsDMARD) use and modern treatments show protective effects.

Keywords:

PsA axial disease radiographic progression sacroiliitis

More Related Videos

Measuring Psoriasis Severity at Home

Measuring Psoriasis Severity at Home

Published on: March 1, 2024

In vivo Macrophage Imaging Using MR Targeted Contrast Agent for Longitudinal Evaluation of Septic Arthritis

In vivo Macrophage Imaging Using MR Targeted Contrast Agent for Longitudinal Evaluation of Septic Arthritis

Published on: October 20, 2013

Related Experiment Videos

Last Updated: Jul 3, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Measuring Psoriasis Severity at Home

Measuring Psoriasis Severity at Home

Published on: March 1, 2024

In vivo Macrophage Imaging Using MR Targeted Contrast Agent for Longitudinal Evaluation of Septic Arthritis

In vivo Macrophage Imaging Using MR Targeted Contrast Agent for Longitudinal Evaluation of Septic Arthritis

Published on: October 20, 2013

Area of Science:

Rheumatology
Immunology
Radiology

Background:

Psoriatic arthritis (PsA) can lead to sacroiliitis, affecting the sacroiliac joints.
Radiographic evidence of sacroiliitis progression is a significant concern in PsA management.

Purpose of the Study:

To assess the progression of radiographic sacroiliitis in a psoriatic arthritis cohort.
To identify factors associated with sacroiliitis progression in PsA patients.

Main Methods:

Analysis of a prospective PsA cohort with biannual pelvic radiographs.
Assessment of Sacroiliitis Sum Score (SSS) change as the primary outcome.
Use of linear mixed-effects models and Cox regression to identify associated factors.

Main Results:

45% of patients showed sacroiliitis progression (SSS increase ≥1 grade).
Factors like male sex, higher inflammatory markers, and disease activity scores were associated with progression.
Older age and biologic/targeted synthetic DMARD (b/tsDMARD) exposure demonstrated protective effects against progression.

Conclusions:

Radiographic sacroiliitis progression is a frequent complication in psoriatic arthritis.
Higher inflammatory activity increases progression risk, while b/tsDMARDs and modern treatment eras are associated with reduced progression.