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Updated: Jul 3, 2026

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
05:44

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Published on: June 10, 2025

Peristomal Pyoderma Gangrenosum Related to Systemic Lupus Erythematosus: A Case Study.

Francesco Carlo Denti1,2,3,4,5,6,7, Dorina Bancea1,2,3,4,5,6,7, Giulia Vidotto1,2,3,4,5,6,7

  • 1Francesco Carlo Denti, RN, MScN, IRCCS San Raffaele Institute, Milan, Italy.

Journal of Wound, Ostomy, and Continence Nursing : Official Publication of the Wound, Ostomy and Continence Nurses Society
|July 1, 2026
PubMed
Summary

Peristomal pyoderma gangrenosum (PPG) is a rare skin complication. A combination of barrier film, topical corticosteroid, and alginate dressing effectively managed PPG in a patient with systemic lupus erythematosus (SLE).

Keywords:
OstomyParastomal pyoderma gangrenosumPyoderma gangrenosumStoma careSystemic lupus erythematosusWound care

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Last Updated: Jul 3, 2026

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
05:44

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Published on: June 10, 2025

Area of Science:

  • Dermatology
  • Gastroenterology
  • Rheumatology

Background:

  • Peristomal pyoderma gangrenosum (PPG) is a rare and challenging complication affecting peristomal skin.
  • No established treatment guidelines exist for managing PPG.
  • This case involves a patient with systemic lupus erythematosus (SLE) on chronic immunosuppressive therapy.

Purpose of the Study:

  • To describe the successful management of a complex case of peristomal pyoderma gangrenosum (PPG).
  • To highlight an effective treatment strategy for refractory PPG in a patient with SLE.

Main Methods:

  • A patient with SLE and a colostomy presented with treatment-resistant PPG.
  • Treatment involved the application of a barrier film, a topical corticosteroid, and an alginate dressing.

Main Results:

  • The synergistic combination therapy led to the successful resolution of PPG lesions.
  • The patient experienced significant improvement in peristomal skin integrity.

Conclusions:

  • The combined use of barrier film, topical corticosteroid, and alginate dressing is an effective strategy for managing PPG.
  • This approach offers a viable treatment option for refractory PPG, particularly in patients with underlying systemic conditions like SLE.