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Role of Adjunctive Intravitreal Therapy in Intraocular Tubercular Granuloma at a Tertiary Uveitis Care Centre - A
Sudha K Ganesh1, Swati Priyadarshini1, Namitha Rachel Mathew1
1Medical Research Foundation, Sankara Nethralaya, Chennai, India.
Purpose:
To evaluate the role of intravitreal anti-VEGF with moxifloxacin in intraocular tubercular granuloma.
Method:
This retrospective interventional study was conducted at a referral uveitis clinic between January 2022 and 2025. All patients who had received intravitreal anti-VEGF with moxifloxacin along with systemic anti-tubercular therapy (ATT) for intraocular tubercular (TB) granuloma were included.
Result:
Ten eyes of ten consecutive patients with tubercular granulomas treated at our institution were analyzed. The median age of presentation was 32.5 years (range 18-44 years). The median duration of follow-up was 4 months (range 2-34 months).Seven cases had TB choroidal granuloma, two had ciliary body granuloma, and one had both choroidal and ciliary body granulomas. All patients received intravitreal anti-VEGF and moxifloxacin along with systemic ATT and oral steroids. Nine eyes had resolved granuloma till the last follow-up. One patient had persistent inflammation despite three intravitreal anti-VEGF injections along with moxifloxacin. The visual acuity improved in eight patients.
Conclusion:
Adjunctive intravitreal therapy with anti-VEGF and moxifloxacin along with ATT aided in resolution of intraocular TB granuloma.
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