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Published on: March 29, 2022
Identification of 11α/β-hydroxy-12β-deoxysaxitoxin (12β-deoxyM2) in bivalve molluscs
Satoshi Numano1, Mari Yotsu-Yamashita2, Hayate Ishizuka3
1Fisheries Technology Institute, National Research and Development Agency, Japan Fisheries Research and Education Agency, 2-12-4 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-8648, Japan.
None:
Paralytic shellfish toxins (PSTs) consist of saxitoxin (STX) and approximately 60 structural analogues. We report here a new STX analogue, 12β-deoxyM2, detected in bivalve molluscs. Because 12β-deoxyM2 and STX are detected on the same selected reaction monitoring (SRM) transition in LC-MS/MS and exhibit very close retention times, detailed mass spectrometric and chromatographic characterization was carried out to enable identification of 12β-deoxyM2. In our present study, presence of 12β-deoxyM2 in bivalves was unambiguously demonstrated.

