The IL10 rs1800872 polymorphism differentially modulates the relationship between plasma IL-10 levels and cognitive...

Area of Science:

• Neuroscience
• Immunology
• Genetics

Background:

• Immune dysregulation is increasingly linked to neurocognitive impairment in methamphetamine use disorder (MUD).
• Interleukin-10 (IL-10), an anti-inflammatory cytokine, has potential neuroprotective roles, but its connection to cognitive deficits in MUD is not fully understood.
• Genetic variations, specifically IL10 rs1800872 polymorphism, might influence IL-10 production and its effects.

Purpose of the Study:

• To investigate if the IL10 rs1800872 T>G polymorphism modulates the association between plasma IL-10 levels and cognitive function in male individuals with MUD.
• To explore genotype-specific differences in cognitive function and IL-10 levels between MUD patients and healthy controls (HCs).

Main Methods:

• Recruited 568 male MUD patients and 210 male HCs.
• Assessed cognitive function using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS).
• Measured plasma IL-10 levels and determined the rs1800872 genotype.

Main Results:

• MUD patients exhibited widespread cognitive impairment and elevated plasma IL-10 levels compared to HCs.
• The rs1800872 genotype did not correlate with IL-10 levels but showed group-dependent associations with attention, with TT homozygotes performing better in MUD patients.
• Genotype moderated the IL-10 and cognitive function relationship differently in MUD patients and HCs, with significant associations observed in specific genotypes and groups.

Conclusions:

• The IL10 rs1800872 polymorphism may be associated with genotype-specific patterns of plasma IL-10 levels and cognitive function in MUD.
• These findings suggest a potential interplay between inflammatory status, genetic background, and substance-related cognitive dysfunction.
• Further research is warranted to elucidate the precise mechanisms underlying these genotype-specific effects.