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High-Resolution Endocardial and Epicardial Optical Mapping in a Sheep Model of Stretch-Induced Atrial Fibrillation
Published on: July 29, 2011
An AV-synchronous leadless pacemaker with electrical far-field atrial sensing in a sheep model
Christophe Garweg1, Theofanie Mela2, Sunil Kapur3
1Department of Cardiovascular Sciences, University Hospitals Leuven, Belgium.
Heart Rhythm
|July 1, 2026
Summary
A new leadless pacemaker demonstrated safe implantation and consistent atrioventricular synchrony (AVS) in a chronic sheep model. This novel device offers a promising alternative to traditional pacemakers, reducing complications.
Area of Science:
- Cardiovascular Medicine
- Biomedical Engineering
- Medical Devices
Background:
- Leadless pacemakers reduce complications compared to transvenous systems.
- Current leadless devices have variable consistency in achieving atrioventricular synchrony (AVS).
Purpose of the Study:
- To evaluate the safety and efficacy of a novel AVS leadless pacemaker system.
- Assess the performance in a Good Laboratory Practice (GLP) animal study.
Main Methods:
- Implanted the LivIQ DX pacemaker (sub-1cc VDD) in nine sheep via jugular access.
- Evaluated safety through implant procedure, blood panels, data collection, and necropsy.
- Assessed efficacy via electrical values and AVS during rest and stress tests.
Main Results:
- Successful implantation with no serious adverse events.
- Stable electrical values and pacing parameters over 12 weeks.
- Achieved 100% AVS at rest and maintained up to 140 bpm during stress tests.
Conclusions:
- The novel leadless pacemaker demonstrated safe implantation and reliable electrical performance.
- High AVS was consistently achieved in a chronic sheep model.
- This technology presents a viable alternative for patients requiring pacing.
