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Related Concept Videos

Auditory Pathway01:15

Auditory Pathway

Auditory pathways constitute the complex neural circuits responsible for transmitting and interpreting auditory information from the peripheral auditory system to the brain. Sound waves are initially captured by the outer ear, funneled through the ear canal, and reach the tympanic membrane (eardrum). These vibrations are transmitted via the middle ear's ossicles to the inner ear's cochlea.
When viewed cross-sectionally, the cochlea reveals the scala vestibuli and scala tympani flanking the...
Hearing01:31

Hearing

When we hear a sound, our nervous system is detecting sound waves—pressure waves of mechanical energy traveling through a medium. The frequency of the wave is perceived as pitch, while the amplitude is perceived as loudness.
Schizophrenia01:17

Schizophrenia

Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those diagnosed.
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...
Positive Symptoms of Schizophrenia: Hallucinations and Delusions01:30

Positive Symptoms of Schizophrenia: Hallucinations and Delusions

Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes loosely...
Auditory Perception01:17

Auditory Perception

The auditory system is essential for sound perception, utilizing various critical structures. When sound waves enter the outer ear, they travel through the ear canal and cause the eardrum to vibrate. These vibrations are then transmitted to the middle ear, where three tiny bones – the malleus, incus, and stapes – amplify the sound. This amplification is crucial, as it ensures that the sound vibrations are strong enough to be conveyed to the inner ear. These vibrations then reach the cochlea, a...

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Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder
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Published on: April 22, 2015

Altered functional hierarchical and sequential organization in individuals with schizophrenia during auditory

Yeongseon Choi1, Paola Fuentes-Claramonte2, Peter McKenna2

  • 1Ulsan National Institute of Science and Technology, 50, UNIST-gil, Eonyang-eup, Ulsan, 44919, Republic of Korea.

Neuroimage
|July 1, 2026
PubMed
Summary

Schizophrenia (SZ) disrupts brain network organization during auditory tasks. Findings reveal abnormal hierarchical organization and infra-slow propagation in SZ patients compared to healthy controls.

Keywords:
Auditory taskFunctional connectivity gradientInfra-slow activitySchizophreniaTraveling wavefMRI

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Brain Imaging

Background:

  • Schizophrenia (SZ) is a severe psychiatric disorder with varied symptoms.
  • Brain network alterations are often observed in SZ, typically studied using resting-state functional connectivity.
  • Task-related brain organization in SZ remains less understood.

Purpose of the Study:

  • To investigate task-related alterations in brain organization during auditory tasks in individuals with schizophrenia.
  • To examine functional connectivity gradients and infra-slow sequential organization in SZ.
  • To identify potential biomarkers for SZ classification and clinical course.

Main Methods:

  • Functional connectivity gradient analysis during auditory tasks.
  • Infra-slow sequential organization analysis, focusing on phase shifts.
  • Decoding analyses to classify schizophrenia patients from healthy controls using phase shift values.

Main Results:

  • Disrupted functional hierarchical organization was observed in SZ patients.
  • Significant differences in phase shifts were found in somatomotor, parietal, and supracallosal anterior cingulate cortex between SZ and healthy controls (HC).
  • Phase shift values reliably classified SZ from HC and correlated with clinical courses in the postcentral gyrus.

Conclusions:

  • Schizophrenia is characterized by abnormal hierarchical organization during auditory processing.
  • Infra-slow propagation patterns differ significantly between individuals with SZ and HC.
  • Task-related brain organization analysis offers potential for SZ diagnosis and understanding disease progression.