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Related Experiment Video

Updated: Jul 3, 2026

Reduced-gravity Environment Hardware Demonstrations of a Prototype Miniaturized Flow Cytometer and Companion Microfluidic Mixing Technology
13:59

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A Closed-System Lumbar Puncture Design for Microgravity.

Brandon Adams, Zoey Levinson, Peter Alexandrov

    Aerospace Medicine and Human Performance
    |July 1, 2026
    PubMed
    Summary
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    A novel closed-system lumbar puncture device was developed for spaceflight, successfully demonstrating safe and accurate intracranial pressure measurements in microgravity. This innovation paves the way for crucial in-flight medical data collection.

    Area of Science:

    • Space Medicine
    • Medical Device Engineering
    • Neuroscience

    Background:

    • Lumbar puncture (LP) is vital for diagnosing conditions on Earth and in space.
    • Previous attempts to perform LP in space were hindered by operational challenges like infection risk and fluid management.
    • In-flight LP is crucial for understanding spaceflight-associated neuro-ocular syndrome and intracranial pressure changes.

    Purpose of the Study:

    • To develop and demonstrate a closed-system lumbar puncture (LP) device suitable for microgravity.
    • To overcome the limitations of traditional LP procedures in the space environment.
    • To enable in-flight intracranial pressure measurements and cerebrospinal fluid (CSF) analysis.

    Main Methods:

    • A novel closed-system LP device was designed, incorporating an injection port and an electronic pressure transducer.
    Keywords:
    central nervous systemcerebrospinal fluidintracranial pressurelumbar puncturespaceflight associated neuro-ocular syndrome

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    Last Updated: Jul 3, 2026

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  • The system eliminates the need for gravity-based manometry, mitigating risks associated with traditional LP.
  • Proof-of-concept testing involved mock LPs using a trainer with known fluid pressures.

    • Main Results:

    • The closed-system LP successfully prevented fluid loss and air entrance during mock procedures.
    • The device demonstrated high accuracy (r = 0.995) and precision (SD = 0.406 mmHg) in measuring pressures within the typical CSF range.
    • The system proved effective for intracranial pressure measurement in a simulated microgravity environment.

    Conclusions:

    • This study presents the first successful demonstration of a closed-system LP for microgravity applications.
    • The developed system mitigates key risks, enabling future in-flight LP procedures.
    • Further validation through custom equipment development and in vivo testing is required for operational use.