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Related Experiment Video

Updated: Jul 3, 2026

Methods for Studying the Mechanisms of Action of Antipsychotic Drugs in Caenorhabditis elegans

Methods for Studying the Mechanisms of Action of Antipsychotic Drugs in Caenorhabditis elegans

Published on: February 4, 2014

Recurrent falls while taking clozapine.

Juliet Kenstavica Pinto¹, Jonathan P Rogers^2,3, Alex J Berry³

¹Royal Free London NHS Foundation Trust, London, UK juliet.kenstavicapinto@nhs.net.

Practical Neurology

|July 1, 2026

Summary

This summary is machine-generated.

Frequent falls in a bipolar disorder patient were linked to negative myoclonus, a rare clozapine side effect. Medication review and examination are crucial for patients experiencing falls on complex drug regimens.

Keywords:

CLINICAL NEUROLOGY NEUROPSYCHIATRY PSYCHIATRY

Related Experiment Videos

Last Updated: Jul 3, 2026

Methods for Studying the Mechanisms of Action of Antipsychotic Drugs in Caenorhabditis elegans

Methods for Studying the Mechanisms of Action of Antipsychotic Drugs in Caenorhabditis elegans

Published on: February 4, 2014

Area of Science:

Neuroscience
Psychiatry
Pharmacology

Background:

Clozapine is an effective antipsychotic for treatment-resistant bipolar disorder.
Adverse effects of clozapine can include movement disorders.
Falls are a common concern in elderly patients, particularly those with psychiatric conditions.

Purpose of the Study:

To report a case of negative myoclonus causing falls in a patient treated with clozapine.
To highlight a rare adverse effect of clozapine.
To emphasize the importance of medication review in psychiatric patients with falls.

Main Methods:

Case report of a 56-year-old male patient with treatment-resistant bipolar disorder.
Clinical observation of frequent falls and development of negative myoclonus.
Pharmacological intervention including clozapine and valproate.
Assessment of medication effects and patient's functional status.

Main Results:

The patient developed frequent falls attributed to negative myoclonus, a rare adverse effect of clozapine.
The movement disorder persisted despite the addition of valproate.
Clozapine dosage reduction was necessary to mitigate falls and functional impairment.

Conclusions:

Negative myoclonus is a potential, albeit rare, adverse effect of clozapine.
Thorough medication review and physical examination are essential for psychiatric patients experiencing falls.
Management of clozapine-induced movement disorders may require dose adjustment or discontinuation.