Related Experiment Video
Updated: Jul 3, 2026
08:01
Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines
Published on: April 21, 2022
Protocol for Mesothelioma Observational study of Risk prediction and Generation of paired benign-meso tissue samples,
Mark D J Neilly1,2, Alexandrea MacPherson2, Laura Alexander3
1Glasgow Pleural Disease Unit, Queen Elizabeth University Hospital, Glasgow, UK.
BMJ Open Respiratory Research
|July 1, 2026
Summary
This study tracks patients with asbestos-associated pleural inflammation to identify early signs of pleural mesothelioma. Researchers aim to collect tissue samples and use multiomic profiling to predict disease progression and develop new treatments.
Area of Science:
- Oncology
- Translational Research
- Biomarker Discovery
Background:
- Pleural mesothelioma (PM) often follows benign asbestos-associated pleural inflammation (AAPI).
- This progression offers a critical window for early intervention and translational research.
- The PREDICT-Meso network focuses on identifying targets for early-stage or pre-invasive disease.
Purpose of the Study:
- To establish a bioresource of longitudinal tissue samples from AAPI to PM evolution.
- To develop preclinical models for drug screening.
- To create reliable tools for risk prediction in AAPI patients.
Main Methods:
- The Meso-ORIGINS study is a prospective, multicentre observational study with two arms.
- Arm A (300 AAPI patients) involves 2-year surveillance with 6-monthly check-ups and repeat biopsies for PM evolution, plus multiomic profiling (proteomics, metabolomics, MRI).
- Arm B (300 suspected PM patients) focuses on multiregion pleural biopsies and pleural fluid/breath collection for cell lines and biomarker evaluation.
Main Results:
- The study aims to collect at least 38 longitudinal AAPI-PM tissue pairs.
- Projected PM evolution rate is 14% (95% CI 10.5-19.2) based on prior feasibility data.
- Multiomic profiling and MRI will be used for risk stratification.
Conclusions:
- The Meso-ORIGINS study will provide crucial longitudinal data and tissue samples for understanding PM development.
- This research aims to enable early detection and targeted therapies for pleural mesothelioma.
- Findings will contribute to developing predictive tools for patients at risk.
