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Japanese-Style Diet and LOX-Index in Japanese Municipal Workers
Mirai Sakanari1, Masanori Ohta1,2, Mayumi Nagano2
1Graduate School of Health and Environmental Sciences, Fukuoka Women's University.
Journal of Nutritional Science and Vitaminology
|July 1, 2026
Summary
This study found no association between adherence to a Japanese-style diet, measured by the JDI12 score, and the LOX-index, a biomarker for atherosclerosis progression, in Japanese workers.
Area of Science:
- Cardiovascular Disease Research
- Nutritional Epidemiology
- Biomarker Analysis
Background:
- Japanese-style diets are linked to reduced cardiovascular disease risk.
- The LOX-index is a predictive biomarker for atherosclerosis progression.
- Previous research has not explored the link between Japanese diet patterns and the LOX-index.
Purpose of the Study:
- To investigate the cross-sectional association between a Japanese-style diet and the LOX-index.
- To assess if the 12-component Japanese Diet Index (JDI12) score correlates with LOX-index levels.
Main Methods:
- A cross-sectional study involving 338 Japanese municipal workers.
- Dietary intake assessed using a validated brief self-administered diet history questionnaire.
- The 12-component Japanese Diet Index (JDI12) score was calculated; LOX-index was determined by multiplying serum LOX-1 and LOX-1 ligand concentrations.
Main Results:
- No significant association was found between the JDI12 score and the LOX-index after adjusting for covariates.
- Geometric means of LOX-index showed no trend across tertiles of JDI12 score (p=0.55).
Conclusions:
- The study suggests that a Japanese-style diet, as evaluated by the JDI12 score, is not associated with the LOX-index in this cohort.
- Further research may be needed to explore other dietary components or populations.
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