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Related Experiment Video

Updated: Jul 3, 2026

An Efficient and Reproducible Protocol for Distraction Osteogenesis in a Rat Model Leading to a Functional Regenerated Femur
09:26

An Efficient and Reproducible Protocol for Distraction Osteogenesis in a Rat Model Leading to a Functional Regenerated Femur

Published on: October 23, 2017

A Biomechanical Proof-of-Concept Study of Scaffold-Augmented Distraction Osteogenesis Using 3D-Printed Hyperelastic

Anirejuoritse Bafor1, Daryn Strub1, Benjamin Brooks2

  • 1Department of Orthopaedics, Nationwide Children's Hospital, Columbus, Ohio, USA.

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
|July 1, 2026
PubMed
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This study investigated Hyperelastic Bone™ scaffolds for distraction osteogenesis (DO) in rabbits. While not improving bone density, the biphasic scaffold enhanced regenerate stiffness and strength, potentially improving DO outcomes.

Area of Science:

  • Biomaterials Science
  • Orthopedic Surgery
  • Regenerative Medicine

Background:

  • Distraction osteogenesis (DO) for limb lengthening requires prolonged fixation.
  • Adjuncts improving regenerate quality could reduce treatment time and morbidity.
  • The efficacy of Hyperelastic Bone™ (HEB) scaffolds in DO is not well-established.

Purpose of the Study:

  • To evaluate the efficacy of traditional and biphasic HEB scaffolds as osteotomy-site adjuncts during rabbit tibial lengthening via DO.
  • To assess the impact of HEB scaffolds on regenerate bone mineral density (BMD) and mechanical properties.

Main Methods:

  • Rabbits underwent tibial lengthening using DO with external fixation.
  • Subperiosteal scaffolds (control, traditional HEB, biphasic HEB) were applied at the osteotomy site.
Keywords:
3D‐printed bone scaffoldDistraction osteogenesisMicro‐CT regenerate assessmenthydroxyapatite/PLGA compositehyperelastic bone™rabbit tibial lengthening model

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Last Updated: Jul 3, 2026

An Efficient and Reproducible Protocol for Distraction Osteogenesis in a Rat Model Leading to a Functional Regenerated Femur
09:26

An Efficient and Reproducible Protocol for Distraction Osteogenesis in a Rat Model Leading to a Functional Regenerated Femur

Published on: October 23, 2017

A Mouse Distraction Osteogenesis Model
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A Mouse Distraction Osteogenesis Model

Published on: November 14, 2018

Establishment of a Segmental Femoral Critical-size Defect Model in Mice Stabilized by Plate Osteosynthesis
06:38

Establishment of a Segmental Femoral Critical-size Defect Model in Mice Stabilized by Plate Osteosynthesis

Published on: October 12, 2016

  • Regenerate quality was assessed via radiographs, micro-CT (BMD), and torsional testing (stiffness) after 8 weeks.

    • Main Results:

    • All tested scaffolds were associated with regenerate formation.
    • Regenerate BMD was not improved by scaffolds compared to controls.
    • Scaffold treatment, particularly the biphasic formulation, significantly increased regenerate torsional stiffness, strength, and polar moment of inertia.

    Conclusions:

    • Hyperelastic Bone™ scaffolds, especially the biphasic formulation, enhance the mechanical properties of the regenerate in distraction osteogenesis.
    • These findings suggest HEB scaffolds could potentially improve functional outcomes and reduce complications in DO procedures.