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Related Concept Videos

Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...

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Related Experiment Video

Updated: Jul 3, 2026

Assessing Human Spatial Navigation in a Virtual Space and its Sensitivity to Exercise
06:17

Assessing Human Spatial Navigation in a Virtual Space and its Sensitivity to Exercise

Published on: January 26, 2024

Goal-directed hippocampal theta sweeps during memory-guided navigation.

Wenbo Tang1, Xiyu Mei1, Ryan E Harvey1

  • 1Department of Neurobiology and Behavior, Cornell University, Ithaca, NY, USA.

Nature Neuroscience
|July 1, 2026
PubMed
Summary
This summary is machine-generated.

New research reveals that experience-dependent theta sweeps in the brain predict upcoming navigation paths. These neural sequences help animals flexibly plan routes toward distant goals in open environments.

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Last Updated: Jul 3, 2026

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06:17

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07:33

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11:37

Tuning in the Hippocampal Theta Band In Vitro: Methodologies for Recording from the Isolated Rodent Septohippocampal Circuit

Published on: August 2, 2017

Area of Science:

  • Neuroscience
  • Cognitive Science
  • Animal Behavior

Background:

  • Flexible navigation relies on neural dynamics to process spatial information and guide behavior.
  • Hippocampal theta sweeps, previously linked to local sampling, are candidates for planning routes to distant goals.

Purpose of the Study:

  • To investigate if theta sweeps facilitate trajectory evaluation toward distant, remembered goals during navigation.
  • To identify the neural mechanisms underlying goal-directed navigation sequences.

Main Methods:

  • Rats were trained to navigate in an open arena toward specific goals.
  • Neural activity, including hippocampal theta sequences and prefrontal cortical activity, was recorded.
  • Sharp-wave ripples were analyzed for sequence replay.

Main Results:

  • A novel form of learning-dependent theta sequences was identified, predicting upcoming goal-directed trajectories.
  • These goal-directed theta sequences coordinated with prefrontal cortex activity.
  • Sequences were preferentially replayed during sharp-wave ripples, suggesting memory consolidation.

Conclusions:

  • Experience-dependent and goal-dependent theta sweeps provide a flexible mechanism for goal-directed navigation.
  • A circuit mechanism involving egocentric goal-direction and reduced inhibition generates these sweeps.
  • Theta sweeps are crucial for planning and executing navigation toward distant goals.