Related Experiment Video

Updated: Jul 3, 2026

Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice
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Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice

Published on: March 11, 2020

Restoring cortical disinhibition improves Huntington's disease phenotypes

Sonja Blumenstock1,2,3,4, David Arakelyan5,6, Nicholas Del Grosso7

  • 1Department of Neurobiology, Center for Neural Circuits and Behavior, University of California San Diego, La Jolla, CA, USA. sblumenstock@ucsd.edu.

Nature
|July 1, 2026
PubMed
Summary

Huntington's disease (HD) motor deficits involve specific cortical neuron issues. Stimulating vasoactive intestinal peptide (VIP) inhibitory neurons improved motor function in HD mice, suggesting a therapeutic target.

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Huntington Disease l: Introduction01:21

Huntington Disease l: Introduction

Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show reduced penetrance,...