Related Experiment Video
Updated: Jul 3, 2026
Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation
Published on: October 20, 2016
Measuring left ventricular global longitudinal strain in different contrast-enhanced echocardiography modes: a
Jiali Zhu1, Yajing Miao2, Hong Zhou2
1Department of Ultrasound, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Background:
Left ventricular global longitudinal strain (LVGLS) is an important parameter to evaluate left ventricular (LV) systolic function, which is more sensitive and reproducible than left ventricular ejection fraction (LVEF). However, whether LVGLS can be accurately measured with ultrasound enhancing agent (UEA) remains controversial. The aim of this study was to verify the feasibility and reproducibility of LVGLS in different contrast-enhanced echocardiography (CE) modes.
Methods:
Two-dimensional speckle tracking echocardiography (2D-STE) was used to measure LVGLS on 75 patients included in this study. Patients were divided into optimal group (n = 33) and suboptimal group (n = 42) according to image quality. LVGLS measurements were performed in 2D mode, left ventricular opacification (LVO) mode, and myocardial contrast echocardiography (MCE) mode. 2D mode LVGLS measurements of the optimal group were used as a reference standard. The comparisons among different modes of each group included Bland-Altman analysis, linear regression and intra-class correlation (ICC). 20 patients were randomly selected from each group to analyze the inter- and intra-observer variability.
Results:
The LVO and MCE modes of optimal group had similar LVGLS measurements with 2D mode (-14.30 ± 4.73%2D vs. -15.32 ± 4.78%LVO vs. -15.36 ± 5.41%MCE, ICC: 0.8142D-LVO vs. 0.7812D-MCE, P < 0.001). There was good agreement between LVO and MCE mode in two groups (ICC: 0.855optimal vs. 0.935suboptimal, P < 0.001). In suboptimal group, both LVO and MCE mode had poor agreement with 2D mode in terms of LVGLS measurements (-13.86 ± 5.46%2D vs. -15.39 ± 7.74%LVO vs. -15.66 ± 7.78%MCE, ICC: 0.7392D-LVO vs. 0.6872D-MCE, P < 0.001). CE improved inter-observer variability in suboptimal group (ICC: 0.6302D vs. 0.864LVO vs. 0.830MCE, P = 0.022, P < 0.001, P = 0.001, respectively).
Conclusions:
It is feasible to measure LVGLS in different CE modes, even in patients with suboptimal acoustic windows, which can reduce the impact of image quality on LVGLS measurements.
More Related Videos
06:34Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
Published on: October 28, 2020
11:50High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart
Published on: July 9, 2010
Related Concept Videos
01:17Imaging Studies for Cardiovascular System I:Echocardiography
Indications: Echocardiography is utilized to diagnose heart failure, valve disorders, and myocardial infarction. It also assesses cardiac structures' size, shape, and motion, evaluates...
01:20Imaging Studies for Cardiovascular System II:Types of Echocardiography
Types of Echocardiography
Transthoracic Echocardiography (TTE)
TTE is the most common type of echocardiogram which involves placing a transducer on the patient's chest, emitting sound waves to create heart images. TTE is invaluable for evaluating the heart's size, structure, and motion, making it particularly useful for diagnosing...