Related Experiment Video
Updated: Jul 3, 2026

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
Published on: June 15, 2019
Update on sepsis treatment
Luis Chiscano-Camon1,2, Juan Carlos Ruiz-Rodríguez1,2, Adolf Ruiz-Sanmartin1,2
1Intensive Care Department, Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.
None:
Sepsis and septic shock remain a global health challenge with high mortality and long-term morbidity. Contemporary evidence highlights immune dysregulation, endothelial dysfunction, and glycocalyx degradation as key pathophysiological drivers. Clinical management has evolved from uniform approaches to precision-guided strategies that integrate subphenotyping, biomarkers and novel therapies. This review synthesizes data from guidelines, translational research, and clinical trials to provide a comprehensive perspective on current management and future directions in sepsis care.
Related Concept Videos
Acute Pyelonephritis II: Diagnostic Studies and Management
Pneumonia IV: Management
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
Endocarditis III: Medical Management
Endocarditis IV: Nursing Management
Pneumonia III: Complications and Assessment
Urinary Tract Infection IV: Nursing Management