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Next-generation Sequencing

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.

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Updated: Jul 3, 2026

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

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The Full Genomic Sequence of the HLA-DQB1*06:524 Allele Identified Using PacBio Sequencing.

Zhiling Li^1,2, Shasha Hu², Shuo Yang^1,2

¹The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, China.

|July 2, 2026

Summary

We present the complete genomic sequence for the HLA-DQB1*06:524 allele. This finding contributes to the understanding of human leukocyte antigen diversity.

Keywords:

HLA‐DQB1*06:524 HLA PacBio sequencing full genomic sequence

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Last Updated: Jul 3, 2026

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

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Associated Chromosome Trap for Identifying Long-range DNA Interactions

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Detection of Copy Number Alterations Using Single Cell Sequencing

Detection of Copy Number Alterations Using Single Cell Sequencing

Published on: February 17, 2017

Area of Science:

Immunogenetics
Molecular Biology
Genomics

Background:

The Human Leukocyte Antigen (HLA) system plays a crucial role in immune response.
Specific HLA alleles are associated with various autoimmune diseases and transplant compatibility.
Detailed genomic information is essential for understanding HLA function and diversity.

Purpose of the Study:

To determine and report the full genomic sequence of the HLA-DQB1*06:524 allele.
To provide a comprehensive genetic resource for this specific HLA allele.

Main Methods:

High-throughput sequencing technologies were employed to obtain the complete genomic DNA sequence.
Bioinformatic analyses were performed for sequence assembly and annotation.

Main Results:

The complete genomic sequence of the HLA-DQB1*06:524 allele has been successfully determined.
The sequence provides detailed information on the genetic structure of this specific HLA allele.

Conclusions:

The full genomic sequence of HLA-DQB1*06:524 is now available.
This data will aid further research in immunogenetics and personalized medicine.