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Related Experiment Video

Updated: Jul 3, 2026

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications
09:30

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

Published on: October 7, 2016

Bioactive Hydrogels with D-Amino Acid RGD Mimics: A Therapeutic Strategy for Expeditious Infected Wound Closure.

Akanksha Negi1,2,3, Santosh Yadav1, Megha Jain1

  • 1Nucleic Acids Research Laboratory, CSIR-Institute of Genomics and Integrative Biology, Delhi, India.

Advanced Healthcare Materials
|July 2, 2026
PubMed
Summary

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This summary is machine-generated.

Novel D-amino acid peptide hydrogels enhance wound healing and combat infections. Increased D-amino acid content improved both antimicrobial activity and tissue regeneration in preclinical models.

Area of Science:

  • Biomaterials Science
  • Peptide Chemistry
  • Regenerative Medicine

Background:

  • Wound healing research faces challenges in developing biomaterials that promote tissue repair while preventing infection.
  • Current strategies often struggle to achieve both antimicrobial and regenerative properties simultaneously.

Purpose of the Study:

  • To synthesize and investigate novel D-amino acid and D/L-hybrid peptide analogs for wound healing.
  • To explore the impact of stereochemistry on peptide hydrogel bioactivity, including antimicrobial and regenerative potential.
  • To evaluate these peptide hydrogels as injectable scaffolds for advanced wound-healing applications.

Main Methods:

  • Synthesis of D-amino acid and D/L-hybrid peptide analogs.
  • Self-assembly of peptides into nanofibrous hydrogels for injectable scaffolds.
Keywords:
D‐amino acidsRGD mimicantimicrobial biomaterialshydrogelself‐assembling peptideswound healing

Related Experiment Videos

Last Updated: Jul 3, 2026

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications
09:30

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

Published on: October 7, 2016

  • Molecular docking to assess peptide binding affinity to integrin αvβ3.
  • In vivo evaluation in methicillin-resistant Staphylococcus aureus (MRSA)-infected mice to assess antimicrobial activity and wound healing.

    • Main Results:

    • Peptide hydrogels demonstrated self-assembly into nanofibrous networks suitable for drug delivery and antimicrobial applications.
    • Molecular docking identified AN2D3 peptide with strong binding affinity to integrin αvβ3, suggesting roles in cell adhesion and proliferation.
    • Increased D-amino acid content correlated with enhanced antimicrobial efficacy and improved wound healing in vivo.
    • AN2D3 peptide sequence exhibited the most significant improvements in wound healing and antimicrobial activity.

    Conclusions:

    • Stereochemistry plays a critical role in the bioactivity of peptide-based hydrogels for wound healing.
    • D-amino acid-rich peptide hydrogels offer a promising strategy for simultaneously addressing infection and promoting tissue regeneration.
    • These biomaterials exhibit potential for advanced wound-healing applications due to their injectable nature, resistance to degradation, and innate antimicrobial properties.