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Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering

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Published on: July 27, 2022

Engineering Functional Graphenic Materials for Bone Repair.

Sebastian Guajardo¹, Jason D Orlando¹, Chenyun Deng¹

¹Department of Chemistry, Carnegie Mellon University, Mellon College of Science, Pittsburgh, Pennsylvania, USA.

Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology

|July 2, 2026

Summary

Graphene oxide (GO) shows great promise for bone tissue engineering by enhancing bone regeneration through osteogenesis and angiogenesis. Functional graphenic materials (FGMs) offer versatile platforms for next-generation bone repair scaffolds.

Keywords:

bone regeneration covalent surface functionalization functional graphenic materials graphene oxide tissue engineering scaffolds

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Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

Area of Science:

Biomaterials Science
Regenerative Medicine
Nanotechnology

Background:

Bone tissue engineering aims to restore bone function using scaffolds, cells, and growth factors.
Current bone repair methods face limitations in efficacy and integration.
Graphene oxide (GO) and functional graphenic materials (FGMs) present novel opportunities.

Purpose of the Study:

To review the role of GO and FGMs in bone regeneration.
To explore their mechanisms in enhancing osteogenesis, angiogenesis, immunomodulation, and biomineralization.
To highlight their potential in developing advanced bone repair scaffolds.

Main Methods:

Literature review of GO and FGMs in bone tissue engineering.
Analysis of GO's chemical properties and functionalization potential.
Examination of FGM-based composite scaffolds for bone regeneration.

Main Results:

GO and FGMs promote bone regeneration through multiple biological pathways.
Surface chemistry of GO allows for tailored functionalization for biomedical applications.
FGM composites show potential as bioactive and bioresorbable scaffolds.

Conclusions:

GO is a versatile platform for developing next-generation bone regeneration strategies.
Functional graphenic materials offer significant potential in bridging material science and regenerative medicine.
Further research into FGM-based composites can advance bone repair therapies.