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Updated: Jul 3, 2026
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Normothermic Machine Perfusion of Rat Kidneys for Transplantation
Published on: January 27, 2026
Evidence-Based Recommendations for the Use of Machine Perfusion in Kidney Transplantation
Rajeev Sharma1, Sourabh Sharma, Puneet Aggarwal
1>From the Department of Nephrology and Renal Transplantation, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.
Summary
Machine perfusion significantly improves organ transplant outcomes, enhancing graft survival and reducing delayed function. This study provides a practical framework for implementing machine perfusion in India, optimizing donor organ utilization.
Area of Science:
- Transplantation science
- Organ preservation technology
Background:
- Machine perfusion is revolutionizing deceased donor organ transplantation.
- It offers improvements in graft survival and reduced delayed graft function.
- It enables greater utilization of marginal organs.
Purpose of the Study:
- To present recommendations for machine perfusion in India.
- To establish a framework for public and private transplant initiatives.
- To optimize the use of machine perfusion for deceased donor organs.
Main Methods:
- Compiled findings from international and national research.
- Developed a framework for organ selection, perfusion techniques, and viability assessment.
- Included financial considerations and implementation strategies.
Main Results:
- Outlined optimal practices for patient selection and organ assessment.
- Detailed hypothermic and normothermic perfusion techniques.
- Addressed perfusate components and financial aspects.
Conclusions:
- Machine perfusion offers a transformative approach to deceased donor organ transplantation.
- The proposed framework facilitates the adoption of machine perfusion in India.
- Implementation strategies aim to enhance organ utilization and transplant success rates.
