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Related Experiment Video

Updated: Jul 3, 2026

Intra-Omental Islet Transplantation Using h-Omental Matrix Islet filliNG (hOMING)
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Fibrin Hydrogel Containing Microvascular Fragments for Improving Subcutaneous Islet Transplants in Diabetic Rats.

Saba Behzadifard1, Mona Navaei-Nigjeh, Mahin Behzadifard

  • 1>From the Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation
|July 2, 2026
PubMed
Summary
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Fibrin hydrogel with microvascular fragments improves survival of transplanted pancreatic islets in diabetic rats. This method enables effective glycemic control using a reduced islet mass, enhancing diabetes treatment strategies.

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Endocrinology

Background:

  • Subcutaneous transplantation of pancreatic islets is a promising approach for diabetes treatment.
  • Poor vascularization in subcutaneous tissue limits islet survival and necessitates larger islet masses for efficacy.

Purpose of the Study:

  • To evaluate the efficacy of fibrin hydrogel combined with microvascular fragments for enhancing subcutaneous islet engraftment.
  • To assess the potential of this composite biomaterial in improving glycemic control in diabetic rats.

Main Methods:

  • Rats were prevascularized subcutaneously with fibrin hydrogel, microvascular fragments, or a combination.
  • Type 1 diabetes was induced, and pancreatic islets (1500 IEQ) were transplanted into prevascularized sites or co-transplanted.

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Last Updated: Jul 3, 2026

Intra-Omental Islet Transplantation Using h-Omental Matrix Islet filliNG (hOMING)
07:36

Intra-Omental Islet Transplantation Using h-Omental Matrix Islet filliNG (hOMING)

Published on: March 14, 2019

Inguinal Subcutaneous White Adipose Tissue (ISWAT) Transplantation Model of Murine Islets
10:14

Inguinal Subcutaneous White Adipose Tissue (ISWAT) Transplantation Model of Murine Islets

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Fat-Covered Islet Transplantation Using Epididymal White Adipose Tissue
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  • Graft function was monitored via blood glucose, glucose tolerance tests, and insulin levels over 28 days.

    • Main Results:

    • Prevascularization with fibrin hydrogel and microvascular fragments significantly increased CD31 expression, indicating enhanced vascularization.
    • Both prevascularization and co-transplant groups achieved normoglycemia within 28 days.
    • Superior glucose tolerance, higher plasma insulin, and increased CD31 and insulin expression were observed in the combination groups.

    Conclusions:

    • Fibrin hydrogel containing microvascular fragments significantly enhances the survival and function of subcutaneously transplanted islets.
    • This approach allows for effective glycemic control with a reduced islet mass, offering a promising strategy for diabetes therapy.