Related Experiment Video For contrast-enhanced ultrasound
Updated: Jul 3, 2026
High-frequency Ultrasound Imaging of Mouse Cervical Lymph Nodes
Published on: July 25, 2015
Application of conventional and contrast-enhanced ultrasound in diagnosing cervical tuberculous lymphadenitis
Jun Hu1, Wenzhi Zhang1, Peijun Chen1
1Department of Ultrasonography, Hangzhou Red Cross Hospital, Zhejiang Hospital of Integrated Traditional Chinese and Western Medicine, Hangzhou, Zhejiang, China.
Objective:
To evaluate the predictive value of contrast-enhanced ultrasonography (CEUS) in differentiating cervical tuberculous lymphadenitis (CTL) from non-tuberculous cervical lymphadenitis (NCTL).
Methods:
A retrospective analysis was conducted on 303 patients with cervical lymphadenopathy. Various CEUS features, including the long axis diameter (L), short axis diameter (S), length-to-width ratio (L/S), presence of the hilum, boundary clarity, internal echogenicity, calcification, necrosis, blood flow distribution within the lymph node, and direction of blood flow, were examined. A multivariate logistic regression model was developed to predict CTL.
Results:
The model identified key predictive factors, including absent hilum, necrosis, heterogeneous enhancement, perfusion defects, peripheral ring enhancement, and non-centrifugal enhancement. In the training cohort (n = 202), the model achieved an AUC of 0.913, with high specificity (77.5%) and sensitivity (92.6%). Similar performance was observed in the validation cohort (n = 101, AUC = 0.917).
Conclusion:
CEUS analysis demonstrates significant efficacy in distinguishing CTL from NCTL, thereby enhancing diagnostic accuracy.
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